摘要
目的:探讨人参果总皂苷对高脂饲养大鼠胰岛素敏感指数的影响。方法:高脂饲养Wistar大鼠,腹腔注射链脲佐菌素30 mg/kg,制成胰岛素抵抗动物模型,观察人参果总皂苷对胰岛素敏感指数的影响。胰岛素敏感性采用高血浆胰岛素-正常血糖钳夹技术,检测稳态时的葡萄糖输注率(glucose infusion rate,GIR)。结果:高脂喂养大鼠与空白对照组大鼠比较,其空腹血糖及空腹胰岛素水平有显著增高(P<0.05,P<0.01),而葡萄糖输注率明显下降(P<0.01)。人参果总皂苷组的各项指标均较模型组有显著改善(P<0.05,P<0.01),并呈剂量依赖关系。结论:人参果总皂苷可明显改善实验大鼠的胰岛素抵抗。
Objective： To observe the effect of ginseng fruit saponins （GFS） on insulin sensitivity index in high fat-fed rats. Methods： An animal model of insulin resistance was established by injecting low dose of streptozotocin （STZ） in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate （GIR） by euglycemic hyperinsulinemic clamp technique. Results： The level of fasting blood glu- cose and insulin in untreated group increased more significantly than that in normal control group （P〈0.05, P 〈0.01） ,while the index of GIR decreased significantly （P〈0.01）. As compared with the untreated group, the parameters of GFS-treated groups were improved significantly in a dosage-dependent manner （P〈0.05, P〈0.01）, Conclusion： GFS can improve experimental insulin resistance in rats.
出处
《中西医结合学报》
CAS
2005年第6期463-465,共3页
Journal of Chinese Integrative Medicine
关键词
人参果总皂苷
胰岛素抵抗
胰岛素敏感指数
ginseng fruit saponins
insulin resistance
insulin sensitivity index
