摘要
为观察肺癌术后早期机体免疫功能的变化，对根治性切除的１１例肺癌病人使用单抗致繁红细胞花环法、全血培养花环法、微量ＬＤＨ释放法及单向免疫琼脂扩散法分别检测手术前、后不同时期的外周血Ｔ淋巴细胞亚群、淋巴细胞介素２受体，ＮＫ细胞活性及血清免疫球蛋白的改变。结果表明：（１）根治术后ＯＫＴ３＾＋、ＯＫＴ４＾＋、ＯＫＴ４＾＋／ＯＫＴ８＾＋比值均较术前显著增加，而ＯＫＴ８＾＋则显著减少。
The subsets of T-lymphocytes, interlekin-2 receptor of lymphocytes, natural killer cell activity and serum immunoglobulins of the peripheral blood were detected in 11 patients before operation and at 1, 7, 14 and 28 days after resection of lung cancer respectively by(1) rosette formation of RBC sensitized by monoclonal antibody or after culture of the whole blood: (2)determination of microrelease of LDH; (3)one war immuno-agar diffusion. The results demonstrated that:①OKT_3￣+、OKT_4￣+ and OKT_4￣+/OKT_8￣+ were significantly increased(P<0.01),but OKT_8￣+was significantly decreased(P<0.01)as compared with the preoperative values.②IL-2R positive cells, NK cell activity and serum immunoglobulins were also significantly increased (P<0.01). It was ponited out that the immunobalance of the patients with bronchogenic cancer can be recovered after radical resection of the tumor.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1996年第2期86-88,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
肺肿瘤
外科手术
免疫功能
Lung carcinoma Radical resection
Immunological response
