摘要
目的探讨HBV前C区nt1896/BCPnt1762基因突变的临床意义。方法在418例血清HBeAg阴性/抗-HBe阳性的慢性乙型肝炎患者,采用微流基因芯片检测HBV前C区nt1896/BCPnt1762基因突变。同时观察血清ALT患者、HBV DNA水平和临床表现。结果nt1896变异195例(46.7%),1762变异192例(45.9%),ALT>正常上限值198例(47.4%),HBV DNA>1×105copiel/ml150例(35.8%),乏力,纳差,肝区胀痛213例(50.9%)。结论HBV前C区nt1896/BCP1762基因突变与HBeAg阴性患者ALT异常,HBV DNA升高及其临床表现具有相关性。
Objective To study the clinical significance of mutation of 1896th nucleotide in precore region（nt1896）and nt1762th nucleotide in basal core promotor （BCPnt1762） of hepatitis B virus（HBV） detected by microflnidic chip, Methods The pre Cntl896 and BCP nt1762 mutation in 418 patients with chronic hepatitis B （CHB） with HBeAg negative and/or anti-HBe positive were observed. Results The cases with pre C nt1896 and BCPntl762 nutation, HBV DNA 〉 1×10^5 copies/ml, ALT 〉 2upper limited normal （ ×ULN）/L and clinical symptoms were 195 （45.6%）, 192（45.2% ）, 150（35.8% ）, 198（47.4% ） and 213 （50.9%）, respectively. Conclusion The pre C nt1896 and BCPnt1762 mutation of HBV have a key role in ALT abnormal, HBV DNA positive and clinical symptoms of patients with CHB.
出处
《实用肝脏病杂志》
CAS
2005年第5期276-277,共2页
Journal of Practical Hepatology
