摘要
目的探讨双氯芬酸钠防治兔眼Nd∶YAG激光晶体后囊膜切开术后并发症的机制。方法24只家兔48只眼行Nd∶YAG激光晶体后囊膜切开术,其中24只眼于手术前后48h,每隔4h滴双氯芬酸钠1滴(手术用药组)另24只眼术后不用药(手术组)。两组均于术后第4、8、12和48h分别采用放射免疫分析法、紫外吸收法检测房水内中等分子量物质(MMS)及花生四烯酸代谢产物—血栓素B2(TXB2),前列腺素E2(PGE2),6-酮-前列腺素F1α(6-keto-PGF1α)含量。结果Nd∶YAG激光晶体后囊膜切开术后不同时间手术组房水内各成分含量均升高,与手术用药组比较差异有统计学意义。结论MMS、PGs与兔眼Nd∶YAG激光晶体后囊膜切开术后出现的并发症有关,手术前后应用双氯芬酸钠能降低这些成分的释放,从而减轻手术后的并发症。
Objective： To investigate the effect of diclofenac sodium on control of complications after Nd： YAG laser posterior capsulotomy in rabbit eyes. Methods ：Totally 48 eyes from 24 rabbits conducted by Nd：YAG laser posterior capsulotomy were divided into 2 group：operationt medication group（ 1 gt of diclofenac sodium every 4 h after operation） and operation without medication group. The changes in middle molecular substances （MMS）, thromboxane B2 （ TXB2 ）, prostaglandin E2 （ PGE2 ）, and 6-keto-prostaglandin F1α （ 6-keto-PGF1α） in aqueous humor of two groups were determined by radioimmunoassay and ultraviolet absorption at 4,8,12 and 48 th hour after operation. Results： The levels of various components in without medication group at different timp were increased significantly in aqueous humor after Nd ： YAG laser posterior capsulotomy, and compared with medication group the statistic differences were significant. Conclusions ：The study suggested that there be relationship between post-operative complications and the components production such as MMS and PGs in different stages of operation in rabbit eye after Nd ： YAG laser posterior capsulotomy. Application of diclofenac sodium before and after operation can reduce the components and relieve the post-operative complications.
出处
《中国激光医学杂志》
CAS
CSCD
2005年第5期303-306,共4页
Chinese Journal of Laser Medicine & Surgery
