摘要
目的:探讨加替沙星不同的给药方式对急性化脓性扁桃体炎的疗效及费用的经济学影响,为合理应用加替沙星提供理论依据。方法:采用随机平行对照试验设计,把256例患者随机分为4组:A组(常用剂量治疗组)、B组(1日1次大剂量组)、C组(序贯疗法治疗组)、D组(一直静滴治疗组),疗程为7天。每组各64例。所有患者均于治疗前后观察临床疗效、细菌学疗效及经济学成本。结果:4组间的临床疗效、细菌学疗效比较表示:A组的疗效明显差于B组、C组、D组(P<0.01);而B组、C组、D组3组之间疗效的差别无统计学意义(P>0.05);在药品费用方面,C药A=C药B<C药C<C药D;在治疗总费用方面,C总A=C总B<C总C<C总D。从成本-效果分析来看,细菌转阴率每增加1个百分点,所需总费用D组最多,为16.26元;B组最少,为11.05元。从增长的成本-效果比来看,若要在B组基础上每增加1个效果单位所花费的总成本,C组最少,A组和D组接近。结论:B方案成本效果比最佳,大剂量每日1次口服给药是最佳的加替沙星治疗方案,序贯疗法是较好的治疗方案。
OBJECTIVE： To study curative effect of gatifloxacin in different dosage plan on acute suppurative tonsillitis and its cost economics, in order to supply some theory basis for rational use of gatifloxacin. METHODS： By taking random parallel control test design, 256 patients were randomly divided into 4 groups： group A （commonly used dose）, group B （large dose of once a day）,group C（sequential therapy） and group D（by intravenous drip from beginning to end）. Course of treatment was 7 days. Each group had 64 patients. All patients had their clinical curactive effect, bacteriologic curative effect and cost of economics observed before and after treatment. RESULTS ： A comparison was made among 4 groups in both clinical curative effect and bacteriologic curative effect. It was found that both curative effects of group A were obviously worse than that of groupB, C and D（ P 〈 0.01 ）, but differences in curative effects among group B, C and D had no statistical significance（ P 〉 0.05）. On the aspect of drug cost, CdrugA = CdrugB 〈 CdrugC 〈 Cdrug Dt On the aspect of total costs of treatment, Ctotal = CtotalB 〈 CtotalC 〈 Ctotal D. According to cost - effectiveness analysis, turning to negative rate of bacterium increased every 1%, total costs were needed the most in group D （16.26yuan）, but the least in group B （11.05yuan）. According to increased cost - effectiveness ratio, on the basis of group B, total costs were spent the least in group C by increasing every one effective unit, but total costs spent in group A were similar to that in group D. CONCLUSION： The ratio of cost- effectiveness in group B is the best. Large dose of once a day, taken orally is the best treatment plan to gatifloxacin, sequential therapy is better.
出处
《中国医院用药评价与分析》
2005年第5期292-294,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
加替沙星
给药方式
治疗
急性化脓性扁桃体炎
经济学分析
成本确定
gatifloxacin
dosage modus
treatment
acute suppurative tonsillitis
analysis of economics
cost definition
