Convenient and Highly Efficient Inversion of 1β-OH Configuration of trans-Vitamin D_(3)

Convenient and Highly Efficient Inversion of 1β-OH Configuration of trans-Vitamin D_3

下载PDF

导出

摘要 A convenient and highly efficient conversion of 1β-OH-trans-vitamin D3, a main byproduct in synthesis of active vitamin D3, to 1α-OH-trans-vitamin D3 is reported. The conversion could be accomplished in 1 minute with 90% yield.

作者 Yong Bin HAN Jin Ping CHEN Ying Ying LI Bai Ning LIU Guo Qiang YANG Yi LI

机构地区 Technical Institute of Physics and Chemistry Key Laboratory of Photochemistry Graduate School

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第11期1437-1440,共4页 中国化学快报（英文版）

基金 to the Major State Basic Research Development Program,Grant No.F2000078100 the National Natural Science Foundation of China(No.20172059)and Chinese Academy of Sciences.

关键词 Vitamin D3 Mitsunobu reaction. Vitamin D3, Mitsunobu reaction.

分类号 O629.4 [理学—有机化学]

引文网络
相关文献

参考文献10

1A. W. Norman, R. Bouillon, M. Thomasset, Vitamin D Endocrine System: Structural,Biological, Genetic, and Clinical Aspects, Vitamin D Workshop, Inc., University of California-Riverside, Riverside, CA, 2000. 被引量：1
2D. Feldman, E H.Glodeux, J. W. Pike,Vitamin D, Academic Press, San Diego, 1997. 被引量：1
3C. M. Hansen, P. H. Maenpaa, Biochem.Pharmacol., 1997, 54, 1173. 被引量：1
4M. E Holick, E. J. Semmler, H. K. Schnose,H. E Deluca,Science. 1973. 180,190. 被引量：1
5G. D. Zhu, W. H. Okamura, Chem. Rev., 1995, 95, 1877. 被引量：1
6D. R. Andrews, D. H. R. Barton, K. P. Cheng, et al., J. Org. Chem., 1986, 51, 1635. 被引量：1
7W.Reischl, H. Kalchhauser, Tetrahedron Lett., 1992, 33, 2451. 被引量：1
8M. J. Calverley, Tetrahedron,1987, 43, 4609. 被引量：1
9O. Mitsunobu. Synthesis. 1981. 1. 被引量：1
10E. Brunn, R. Huisgen, Angew. Chem. Int. Ed. Engl., 1969, 8, 513. 被引量：1

1Yun Yan GAO,Yong Yong LIU,Bo Jie WANG,Bao Wen ZHANG,Yi LI.Effect of Reaction Media on Photoreaction of Provitamin D_3[J].Chinese Chemical Letters,2001,12(4):309-312.
2Shan Qian Li Hai Lei Tang Jin Cheng Yang Yong Wu.Synthesis of an optically active intermediate for A-ring of 19-nor-1α,25-dihydroxyvitamin D3[J].Chinese Chemical Letters,2007,18(3):261-262.
3Wei Fan Li Hai Yong Wu.Synthesis of 14-epi-19-nor-22-oxa-1α,25-dihydroxyvitamin D_3[J].Chinese Chemical Letters,2008,19(3):259-260.
4HU Wen-Xiang WANG Jian-Ying XU Ming RUAN Yi-Min LU Jian-Quan.Synthesis of 1 α, 25-Dihydroxyvitamin D3[J].有机化学,2003,23(z1):141-141.
5YongBinHAN,JinPingCHEN,YunYanGAO,BaiNingLIU,GuoQiangYANG,YiLI.Photosensitization of trans-Vitamin D_3 to cis-Vitamin D_3 in Heterogeneous System[J].Chinese Chemical Letters,2005,16(7):871-874.
6Zhao Junyu,Dong Jianjun,Wang Haipeng,Shang Hongxia,Zhang Dongmei,Liao Lin.Efficacy and safety of vitamin D3 in patients with diabetic nephropathy： a meta-analysis of randomized controlled trials[J].Chinese Medical Journal,2014(15):2837-2843. 被引量：9
7Run Hua DENG,Ai Qiao MI,Yao Zhong JIANG Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610015.SOLID-LIQUID PHASE TRANSFER CATALYTIC SYN THESIS Ⅸ: THE SYNTHESIS OF α-AMINO ACIDS VIA ALICYLATION OF ALDIMINE UNDER MICROWAVE IRRADIATION,[J].Chinese Chemical Letters,1993,4(5):381-384.
8Li Fanghua.Electron Crystallography Study on the Structure Determination of Minute Crystals[J].Science Foundation in China,2007,15(1):24-28.
9郭丰启,董世明,王夺元.A novel pentaazadentate bismacrocyclic cadmium complex[J].Chinese Journal of Chemistry,2000,18(4):551-554.
10Yun Yan GAO,Chang Jiang YOU,Jin Ping CHEN,Yong Yong LIU,Bao Wen ZHANG,Yi LI.Synthesis of a Polymer-bound Sensitizer and its Application in the Photoisomerization of trans-Vitamin D_3 to cis-Vitamin D_3[J].Chinese Chemical Letters,2002,13(12):1158-1161. 被引量：1

Chinese Chemical Letters

2005年第11期

浏览历史

内容加载中请稍等...

Convenient and Highly Efficient Inversion of 1β-OH Configuration of trans-Vitamin D_(3)

参考文献10

相关作者

相关机构

相关主题

浏览历史