摘要
目的评价山东省消灭丝虫病的措施与效果。方法1.流行病学调查;2.以消灭传染源为主导的防治措施;3.蚊媒防制;4.防治效果考核;5.防治后期全民和重点人群传染源检索、残存微丝蚴(mf)血症者反复查治、病原和蚊媒及血清学纵、横向检测、丝虫病传播阈值;6.慢性丝虫病人调查、治疗等一系列防治研究。结果1.防治前平均mf率、蚊媒自然感染率和慢性丝虫病患病率分别为7.1%、19.42%和10.9%;2.历经22年的防治,1983mf率以行政村为单位均降至1%以下,在全国率先达到了基本消灭丝虫病的部颁标准;3.基本消灭后,历经传染源检索、病原、蚊媒和血清学纵、横向监测及传播阈值等研究结果显示,平均mf率由基本消灭第1年的0.13%降至0;4.重点人群平均mf率由基本消灭后9年内的0.06%降至0(基本消灭10年后);5.蚊媒自然感染率由监测第1年的0.14%降至0(基本消灭10年后);6.年传播潜势用帐者和露宿者在研究第1年分别为0.94及3.47,至第10年时均降为0;7.采有各种有效治疗方法尤其是研制应用消肿乳糜清系列制剂通过对绝大数慢性丝虫病患者的治疗,患病率由防治前(1957年)10.9%降至防治后第28年(1986年)的0.31%。结论通过全国消灭丝虫病审评专家组审评,达到了消灭丝虫病的部颁标准。
Objective To evaluate the results of control measures for elimination of lymphatic filariasis in Shandong Province. Methods 1. epidemiological survey ; 2. taking elinination of source of infection as the main measures ; 3. control of mosquito vector; 4.assossment of control reults. 5 .detection of source of infection, repeated detection and treatment of residual microfdaremias （aft）, cross-sectional and longitudinal serological detection of pathogen and vector, survey of fdarial transmission threshold in target poplations at late stage of control; 6. survey and tratment of chronic filariasis patient. Results 1. the average microfilaremia rate, mosquito vector natural infection rate and the incidence of chronic fdariasis in ealry 1950s were 7.1%, 19.42% and 10.9% respectively ; 2. the average mlcrofdaremia rate dropped to less than 1% tacking the village as unit 22 years after control, to have frrstly reached the criteria of basic elimination of fialariasis enacted by Ministry of Health in this country in 1983 ; 3. After basic elimination of filarlasis efforts in control and surveillance were made and average microfilaremia rate further dropped from 0.13% in th frrst year of eliniamtion to zero; 4.The average microfilaremia rate in target population dropped from 0.06% 9 years after elimiantlon to zero 10 years after elimination; 5. the natural infection rate in vector mosquitoes reduced from 0.14% in the first year of surveillance to zero 10 years after surveillance ; 6. the annual transmission potential of bed net users and those sleep outdoors reduced from 0.94 and 3.47 in the first year of observation to zero in the 10th year of study; 7. filarial incidence reduced from 10.9% in 1957 before control to 0.31 % in 1986, 28 years after control with various meausres for treatment of chonic filarlal patients including the research for effective herbal medicine. Conclusion Shandong Province has been attained the criteria of ehnination of fllariasis enacted by Ministry of Health afte assessed by National Expert Gro
出处
《中国热带医学》
CAS
2005年第7期1447-1450,共4页
China Tropical Medicine
基金
本项研究得到联合国开发计划署/世界银行/世界卫生组织热带病研究培训特别规处的部分支持.
