摘要
目的:评价多重作用机制的新型抗癫痫药托吡酯对经期性癫痫患者的临床疗效及对生活质量的影响。方法:收集2001-12/2004-09哈尔滨医科大学第一临床医学院收治的经期性癫痫患者70例,根据患者服用抗癫痫药物情况分为添加治疗组39例和单药治疗组31例。所有患者给予托吡酯治疗,初始剂量第l周为25mg/d,以后每周增加25mg/d,目标剂量为200mg/d,经8周加量期加至目标剂量后,连续服用3个月,然后评定疗效,应用癫痫患者生活质量量表30(共30条,7个分项,总分100分,评分越高,生活质量越好)评估患者的生活质量,同时记录不良反应。结果:按意向处理分析,70例全部进入结果分析。①癫痫患者生活质量量表30得分:添加治疗组及单药治疗组治疗后总分均高于治疗前(61±14,62±14;47±12,44±15;P<0.05),在对发作担心、情绪、担心药物、社会功能等分项上得分均高于治疗前(P<0.05)。②疗效:添加治疗组及单药治疗组总有效率分别为85%和87%,不良反应轻,耐受性好。结论:托吡酯能提高经期性癫痫患者生活质量,其改善生活质量的作用主要通过控制发作及不良反应轻微实现的。
AIM： To evaluate the clinical efficiency of topiramate and its effect on quality of life （QOL） of patents with catamenial epilepsy, so as to study its action mechanism. METHODS： From December 2001 to September 2004, 70 patients with catamenial epilepsy were selected from the Department of Neurology, the First Clinical Medical College of Harbin Medical University. Seventy patients underwent the treatment of topiramate, of whom, 39 cases received a topiramate add-on therapy and 31 cases a monotherapy, continuously for 3 months. The daily dose of topiramate was 25 mg in the first week, which increased 25 mg per week; the goal daily dose of topiramate was 200 mg. The efficiency and QOL were evaluated after 8 weeks of titration period and 12 weeks of stabilization period. QOLIE-30 was used to evaluate the QOL of patients （totally 30 items in 7 aspects, total score is 100, and the higher the score, the better the QOL） . Side effects were recorded at the same time. RESULTS： According to the intention-to-treat analysis, all the 70 cases were involved in the results analysis. ①Seores on QOLIE-30： The total score on QOLIE-30 after treatment were higher than before in the two groups （61±14, 62±14; 47±12, 44±15,P〈0.05） , and scores on some items, such as worry about onset, emotion, worry about drugs, social function, were also higher after treatment （P〈0.05） . ②Clinical efficiency： The total effective rate was 85% and 87% in the add-on group and monotherapy group, respectively. Side effects were generally mild, and patients had a good tolerance to drugs. CONCLUSION： Topiramate can improve the QOL of patients with catamenial epilepsy by lowering seizure frequency and side effects of medication.
出处
《中国临床康复》
CAS
CSCD
北大核心
2005年第37期8-9,共2页
Chinese Journal of Clinical Rehabilitation
