摘要
目的探讨乳腺浸润性筛状癌(invasive cribriform carc inom a,ICC)的临床病理及免疫表型特点。方法收集6例ICC的临床资料,观察它们HE形态,并进行免疫组化检测,选用的一抗有CK5、CK(34βE12)、CK8、S-100蛋白、SMA、CD10、ER、PR、c-erbB-2、CgA、PCNA、E-cad。结果本研究将ICC分为两组:经典型和混合型。它们具有以下特征:①以浸润性筛状结构占优势,细胞排列成浸润性的有棱角的岛屿状,筛孔较不规则。肿瘤细胞小,呈低或中级核级,核分裂象罕见。在多数癌巢周围有反应性纤维母细胞性间质增生。②免疫表型:肌上皮标记(S-100蛋白、SMA、CD10)及CK(34βE12)肿瘤细胞巢均阴性,而个别肿瘤累及的TDLU周围部分肌上皮标记阳性;激素受体(ER、PR)均阳性;c-erbB-2阴性,PCNA、E-cad呈不同程度的阳性;CgA均阴性。③临床资料:经典型ICC年龄均值较混合型ICC大,肿块大小较混合型ICC小,病程较混合型ICC短,腋窝淋巴结转移少见,转移灶仍保持筛状结构。结论ICC有其独特的组织学特征及免疫表型,是一种独立的临床病理类型。
Purpose To investigate the clinicopathologic and immunophenotypic characteristics of invasive cribriform carcinoma （ICC） of the breast. Methods The clinical data, histological feature, immunohistochemical characteristics were analyzed in 6 cases of ICC. Results Six cases of ICC were divided into two groups ： pure ICC and mixed ICC. Patients with pure ICC were older, had shorter course of disease and smaller tumors than patients in the mixed group. Axillary lymph node metastases were few, the cribriform pattern being retained at these sites in pure ICC. Predominantly invasive cribriform pattern were seen in 6 cases of ICC, the tumor is arranged as angulated invasive islands, the tumor cells were small and show a low or moderate degree of nuclear pleomorphism. Mitoses are rare. Reactive fibroblastic stroma is present in 6 cases of ICC. In 6 cases of ICC immunostaining for myoepithelial cells such as S- 100 ,SMA ,CD10 was negative, but positive in intraductal cribriform carcinoma. Estrogen receptor and Progesterone receptor were positive in all 6 cases, but negative for c-erbB-2. PCNA and E-cad were positive in all 6 cases, but negative for CgA and CK（34βE12）. Conclusions ICC is a histologically and clinically distinctive type of breast carcinoma that should be separated from other tumors.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2005年第5期555-558,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
乳腺肿瘤
浸润性筛状癌
腺样囊性癌
breast neoplasms
invasive cribriform carcinoma
adenoid cystic carcinoma
