摘要
目的探讨ⅠE期鼻T/NK细胞淋巴瘤的诊断、误诊原因及不同治疗方法及其对患者预后的影响。方法60例ⅠE期患者行单纯放疗9例,单纯化疗11例,放疗加化疗9例,化疗加放疗12例,化疗加放疗加化疗19例。结果全组1,3,5年生存率分别为84.55%、50.59%、26.20%。其中ⅠE局限组1,3,5年生存率分别为100.00%、77.78%、59.83%,ⅠE超腔组1,3,5年生存率分别为80.10%、53.83%、14.58%,两组间差异有显著性(P=0.0008)。单纯化疗组及单纯放疗组1,3,5年生存率分别为75.00%、25.00%、0.00%及63.64%、21.21%、0.00%,两组间差异无显著性;放化组及化放组1,3,5年生存率分别为88.89%、66.67%、22.22%及90.91%、63.64%、34.09%,两组间差异无显著性;化放化组1,3,5年生存率分别为100.00%、84.21%、56.14%,与放化组及化放组差异无显著性。单纯化疗组、单纯放疗组与放化组及化放组间差异有显著性(P=0.0097)。各组间比较差异有显著性(P=0.0004),生存曲线显示,化放化组优于其他组。结论ⅠE鼻T/NK细胞淋巴瘤早期临床表现不典型,易误诊;综合治疗宜作为首选,早期治疗是关键,以尽早达到局部控制。
OBJECTIVE To discuss the diagnosis, misdiagnosis and the effect of different therapy methods on the prognosis of patients with Ⅰ E nasal T/NK cell lymphoma. METHODS Sixty cases with Ⅰ E nasal T/NK cell lymphoma were divided into 5 groups, which included： radiotherapy alone in 9 cases,chemotherapy alone in 11 cases,chemotherapy＋radiotherapy in 9 cases,chemotherapy＋radiotherapy in 12 cases,and chemotherapy＋radiotherapy＋chemotherapy in 19 cases. RESULTS The 1,3,and 5 year survival rates of all the patients were 84.55%,50.59%, and 26.20% respectively. The 1,3,and 5 year survival rates of the ⅠE intra-cavity group and ex-cavity group were 100%,77.78%,59.83% and 80.10%,53.83%,14.58% respectively,and the survival rates of the two groups had a significant diffenrence（P=0.0008）. The survival rates of the chemotherapy group versus radiotherapy group,chemotherapy＋radiotherapy group versus chemotherapy＋radiotherapy group had no difference. The survival rate of chemotherapy＋radiotherapy＋chemotherapy group was significant higher than that of other groups.CONCLUSION The early clinical manifestations of nasal T/NK cell lymphoma had non-specific symptoms and signs and easy to be misdiagnosed. The combined therapy should be recommended.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2005年第9期549-552,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
