摘要
目的:观察具有活血化瘀和涤痰化浊功效的通脉降脂汤对高脂血症鹌鹑血脂及内皮功能的影响。方法:①实验于2003-05/08在郑州铁路职业技术学院医学院实验中心完成。选用4周龄雄性朝鲜鹌鹑100只。随机分为4组:正常组、高脂组、中药组、西药组,每组25只。②正常组每天每只给予20g普通饲料喂养,高脂组、西药组、中药组每天每只给予20g高脂饲料(由质量分数0.10蛋黄粉、质量分数0.05猪油、质量分数0.015胆固醇、质量分数0.835普通饲料配置而成),此外正常组和高脂组每天每只用1.5mL蒸溜水灌胃;西药组每天每只用1.5mL洛伐他汀灌胃;中药组每天每只用1.5mL通脉降脂溶液(由丹参15g、川芎9g、三七10g、泽泻10g、生大黄10g、草决明10g等进行组方,提供其有效成分制成)灌胃。③实验第50天,采用酶法检测血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇。采用酶联免疫吸附法法检测血浆血管性假性血友病因子水平。④各组计量资料差异性比较采用t检验。结果:正常组、高脂组采血成功16只和中药组、西药组采血成功20只进入结果分析。①通脉降脂汤对血脂影响:中药组鹌鹑血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇显著低于高脂组犤(13.26±4.87),(1.89±0.79),(5.80±4.35)mmol/L;(17.92±7.23),(2.02±0.85),(8.71±3.01),P<0.05犦,高密度脂蛋白胆固醇显著高于高脂组犤(6.30±0.96),(5.19±1.52)mmol/L,P<0.05犦。②通脉降脂汤对内皮功能的影响:中药组鹌鹑血浆血管性假性血友病因子水平显著低于高脂组犤(28.56±20.87)%,(96.79±75.58)%,P<0.01犦,与正常组和西药组相近犤(1.14±10.62)%,(41.19±21.28)%,P>0.05犦。结论:通脉降脂具有良好的降低血脂,改善血管内皮功能功效。
AIM： To observe the effects of Tongmai Jiangzhi decoction, which has the function of promoting blood circulation by removing blood stasis and removing phlegm, on the blood lipid and endothelium function of quails with hyperlipemia. METHODS： ① The experiment was done in the laboratory center of the Medical College of Zhengzhou Railway Vocational Technique College between May and August 2003. 100 male DPR Korea quails aged 4 weeks old were selected and assigned randomly into 4 groups： normal group, high-lipid group, traditional Chinese medicine group and western medicine group with 25 quails in each group. ② The quails in the normal group were raised with 20 g common feed each one every day. Those in the highlipid group, western medicine group and traditional Chinese medicine group were raised with 20 g high-lipid feed （composed of 0.10 massfraction of yolk powder, 0.05 massfraction of lard, 0.015 massfraction of cholesterol and 0.835 massfraction of common feed） each one every day. The guails in the normal group and the high-lipid group were treated with gastric perfusion of 1.5 mL distilled water each one every day; Those in the western medicine group were treated with gastric perfusion of 1.5 mL lovastatin each one every day; Those in the traditional Chinese medicine group were treated with gastric perfusion of 1.5 mL Tongmai Jiangzhi solutions （composed of the 15 g dan-shen root, 9 g Szechwan lovge rhizome, 10 g sanchi, 10 g oriental waterplantain rhizome and 10 g fresh rhubarb etc., using the effective component） each one every day. ③ At the 50^th of experiment, the serum total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol were detected by the enzyme method. The level of the plasm yon willebrand＇s disease factor was tested by the enzyme-linked immunoadsordent assay. ④ The differences of the calculated materials in every group were compared by the t-test. RESULTS： Sixteen quails getting blood successfully in the normal group an
出处
《中国临床康复》
CSCD
北大核心
2005年第31期134-135,共2页
Chinese Journal of Clinical Rehabilitation
基金
郑州铁路局科委资助项目(00W43)~~
