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内皮素与儿童支气管哮喘的相关性 被引量:2

Relative Study between Endothilin and Asthma in Children
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摘要 支气管哮喘(简称哮喘)严重影响儿童、青少年的生长发育。内皮素(ET)是哮喘发病过程中的重要因子。ET在哮喘患儿血浆中高水平表达,可减少呼吸道上皮细胞的繁殖、移植和呼吸道平滑肌细胞异常增殖和呼吸道重塑;ET是哮喘的启动因子,刺激肺组织分泌炎性介质,加重哮喘;通过对染色体基因片段影响,导致哮喘家族性遗传。动物实验中发现ET抗体能抑制哮喘发生发展,在人类是否有效有待进一步探讨。
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2005年第10期1044-1046,共3页 Journal of Applied Clinical Pediatrics
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