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11β-羟基类固醇脱氢酶与代谢综合征 被引量：5

11beta-hydroxysteroid dehydrogenase in metabolic syndrome
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摘要 11β羟基类固醇脱氢酶(11βHSD)在胰岛素靶组织内催化皮质醇(皮质酮)与可的松(脱氢皮质酮)相互转化,调节局部糖皮质激素活性。11βHSD的表达、活性及分布与代谢综合征各方面相关联。抑制或下调11βHSD1的活性为治疗代谢综合征提供了一种新的方法。作者对这方面研究进展作一综述。 11β-hydroxysteroid dehydrogenase （ 11β- HSD） catalyzes the interconversion of cortisone （ dehydro corticosterone） into cortisol（corticosterone） within insulin target tissues, thereby modulates the activity of glucocorticoids. 11β-HSD expression and activity are associated with the aspects of metabolic syndrome. Inhibition of 11β- HSD1 or to down-regulate 11β-HSD1 activity has been proposed as a novel strategy to treat the metabolic syndrome. This essay reviews the evolvement of the study.
作者 马里 孙子林 王尧
机构地区 东南大学附属中大医院内分泌科
出处 《现代医学》 2005年第3期204-207,共4页 Modern Medical Journal
关键词 11Β-羟基类固醇脱氢酶 糖皮质激素 代谢综合征 11β-hydroxysteroid dehydrogenase glucocorticoids metabolic syndrome
分类号 R589 [医药卫生—内分泌]
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参考文献15

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同被引文献40

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引证文献5

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现代医学
2005年 第3期

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