摘要
本文利用 Morris 水迷宫对大鼠脑缺血20分钟经短期(10天)和长期(90天)再灌流后进行了空间学习、记忆的研究。脑缺血采用四血管结扎模型。结果表明:脑缺血后再灌流10天大鼠只在定位航行试验中显示学习过程减慢,而在空间探索试验中没有显示记忆损伤;经90天再灌大鼠则在定位航行试验和空间探索试验中表现出显著的学习、记忆障碍。形态学证明脑缺血20分钟再灌10天,海马细胞丢失仍局限于 CA1区,而经90天再灌后,细胞丢失扩展到 CA3。认为行为学上的这种变化归因于海马的形态学改变。
The effect of 20min.cerebral ischemia followed by 10 days or 90 days survival on spatial learning and memory in Morris water maze was investigated in rats. The transient cerebral ischemia was induced by 4 yes sel occlusion.The results showed that,ischemia,afrer 10 days reperfusion,slightly affected the performance in acquisition trial,without impairment in probe test. But,after 90 days survival,the ischemia rats demon- strated both severe learning and memory performance impairment in acquisition trial and probe test.In 10 days survival rats.the cell lose was only limitted in CA1,after 90 days reperfusion,it extended to CA3 re gion.It is believed that the morphological alteration of hippocampus induced by ischemia and reperfusion was the cause of learning and memory impairment in Morris water maze test.
出处
《中国行为医学科学》
CSCD
1996年第1期2-4,共3页
Chinese Journal of Behavioral Medical Science
关键词
脑缺血
行为学
学习
记忆
Cerebral Ischemia
Hippocampus
Morris water maze Learning,Memory
