凝血因子Ⅶ及其受体在肿瘤治疗中的研究
Progress of coagulation fartorⅦ and its receptors in tumor therapy
摘要
凝血因子Ⅶ(FⅦ)及其受体组织因子(TF)在外源性凝血过程中起着起始因子的作用。最近研究表明,二者还与肿瘤的生长、浸润、转移等密切相关,并作为潜在的肿瘤治疗靶点和预后指标日益受到广泛关注。现就FⅦ与TF的结构功能、结合机制以及在肿瘤治疗中的意义、应用等方面研究作一综述。
出处
《国外医学(肿瘤学分册)》
2005年第8期588-591,共4页
Foreign Medical Sciences (Cancer Section)
基金
重庆市院士基金课题资助(6317)
参考文献30
-
1Contrino J, Hair G, Kreutzer DL, et al. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med, 1996,2 ( 2 ): 209 - 215. 被引量:1
-
2Chang CC, Shih JY, Jeng YM, et al. Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. J Natl Cancer Inst, 2004,96 ( 5 ): 364- 375. 被引量:1
-
3Pike AC,Brzozowski AM, Roberts SM, et al. Structure of human factor Ⅶa and its implications for the triggering of blood coagulation. Proc Natl Acad Sci USA,1999,96 (16) :8925-8930. 被引量:1
-
4Seetharam S,Murphy K,Atkins C,et al. Cloning and expression of rat coagulation factor Ⅶ. Thromb Res, 2003,109 ( 4 ): 225- 231. 被引量:1
-
5Owenius R,Osterlund M,Svensson M,et al. Spin and fluorescent probing of the binding interface between tissue factor and factor Ⅶa at multiple sites. Biophys J, 2001,81 ( 4 ): 2357- 2369. 被引量:1
-
6Mousa SA. Tissue factor/Ⅶa in thrombosis and cancer. Methods Mol Med ,2004,93 ( 17 ): 119-132. 被引量:1
-
7Bharadwaj D,Iino M, Kontoyianni M,et al. Factor Ⅶ central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. J Biol Chem. 1996,271 (48) :30685-30691. 被引量:1
-
8Abdulkadir SA, Carvalhal GF, Kaleem Z, et al. Tissue factor expression and angiogenesis in human prostate carcinoma. Hum Pathol,2000,11 (4) :443- 447. 被引量:1
-
9Rickles FR, Shoji M, Abe K. The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer. Int J Hematol,2001,73 (2): 145-150. 被引量:1
-
10Yu JL,May L,Lhotak V,et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood ,2005,105 (4): 1734-1741. 被引量:1
-
1汤坚强,樊庆,万远廉,刘玉村,汪欣,吴涛,潘义生,吴问汉,朱静.组织因子/凝血因子Ⅶ在大肠癌中的异位表达及其临床意义[J].北京大学学报(医学版),2009,41(5):531-536. 被引量:5
-
2李会桥,张予辉.组织因子阳性膜微粒及其在肿瘤中的作用和检测[J].国际肿瘤学杂志,2015,42(7):525-528. 被引量:1
-
3吴涛,万远廉,刘玉村,汪欣,潘义生,李挺,董颖.结直肠癌中组织因子和p53蛋白表达的相关性及其意义[J].解放军医学杂志,2006,31(7):666-667.
-
4王宁,王雅杰.两种Icon嵌合抗体在肿瘤靶向免疫治疗中的应用[J].中国肿瘤生物治疗杂志,2004,11(4):307-309.
-
5武文明,曾昭淳.组织因子与肿瘤靶向治疗[J].生命的化学,2006,26(6):546-548. 被引量:2
-
6杨莉,何奇,丰美芳,胡晶莹,胡修全.TF和Her-2在乳腺癌中的表达及临床意义[J].肿瘤,2009,29(5):475-478.
-
7李辉,张静,汤坚强,万远廉,于歌,汪欣,朱静.热疗联合组织因子靶向治疗对人大肠癌细胞增殖及凋亡的影响[J].中华临床医师杂志(电子版),2012,6(8). 被引量:4
-
8冯津萍,赵炳让,毛用敏,崔让庄,秦勤,路雅茹.TFPI启动子-287T→C不同基因型水平与不稳定心绞痛的关系[J].天津医药,2006,34(7):454-456.
-
9项贵明,粟永萍,程天民,艾国平.组织因子在不同类型人癌组织中的表达[J].中华肿瘤防治杂志,2007,14(6):425-427. 被引量:2
-
10郭艳丽,闫慧明,杨林花,宋善俊.组织因子、血管内皮生长因子在乳腺癌表达的意义[J].山西医科大学学报,2005,36(3):301-304. 被引量:2