摘要
许多核受体属于核转录因子,它们在胞浆合成后快速地转运入核,同时还能够在核浆之间穿梭以行使其特定的生物学功能。核受体的核浆转运主要通过核膜上的核孔复合体,依靠运输载体Importins和Exportins介导以及Ran-GDP提供能量。现对糖皮质激素受体(GR)、雄激素受体(AR)和雌激素受体(ER)等核受体在核浆穿梭转运和调控机制等方面的研究进展进行综述,同时也介绍我们实验室最近发现的视黄素X受体(RXR)核浆穿梭转运的新功能。
Nuclear receptors, which belong to nuclear transcriptional factors, not only translocate into the nucleus rapidly after synthesized in the cytoplasm, but also shuttle between the cytoplasm and the nucleus to exert their specifically biological functions. Nucleocytoplasmic shuttling of nuclear receptor relies on the nuclear pore complexes, the transport carriers （including Importins and Exportins） and the energy pool-Ran-GDP. Here, we summarize the current research progresses on nucleocytoplasmic shuttlling of nuclear receptors （including GR, AR, ER） and their regulatory mechanisms. In addition, we also introduce a novel function of RXRα in its nucleocytoplasmic shuttling found by our laboratory.
出处
《细胞生物学杂志》
CSCD
2005年第4期363-368,共6页
Chinese Journal of Cell Biology
基金
国家自然科学基金资助项目(No.30370715)~~
