摘要
目的探讨苦参素联合微卡(母牛分枝杆菌菌苗)治疗慢性乙型肝炎的疗效。方法对照组(28例)给予综合保肝支持治疗16周;治疗组(32例)在对照组的基础上加用苦参素葡萄糖注射液100ml(含苦参素0.6g),每日静脉滴注1次,连用8周,随后改用苦参素胶囊200mg,口服,每日3次,疗程8周;并同时应用微卡(母牛分枝杆菌菌苗)22.5μg,每2周肌肉注射1次,共16周。结果治疗组治疗前后ALT值的变化差异具有显著性(P<0.01);治疗组HBeAg及HBVDNA阴转率分别为43.7%和40.6%;对照组HBeAg及HBVDNA阴转率分别为10.7%和7.1%,两组差异均具有显著性(P<0.05)。结论苦参素联合微卡治疗慢性乙型肝炎,在改善ALT及HBVDNA、HbeAg阴转率方面疗效显著。
Objective To study the efficacy of oxymatrine combines with vaccae（mycohacterium vaccae） in the treatment of chronic B hepatitis. Methods Comprehensive supporting treatment was performed in control group（28 cases） for 16 weeks. On the basis of treatment in control group（32 cases）, 100ml （0.6 oxymatrine）was administered intravenously once daily for 8 weeks,subsequently was replaced by oxymatrine caosule,simultaneously vaccae（22.5μg） was performed with intramuusular injection , once every two weeks for 16 weeks. Results Changes of ALT was obviously significant （P 〈 0.01 ） pre- and post-treatment in treatment group. Negative conversion rates of HBeAg and HBV DNA were 43.7% （14/32） and 40.6 % （13/32） respectively in treatment group, in control were 10.7 % （3/28） and 7.1% （2/28）. The clinical therapeutic effectiveness on chronic B hepatitis treated by Oxymatrine combined with Cow ramification rod bacteria immunity seedling is reliable in the improvement of ALT and virus signs. There was obvious difference in two groups（ P 〈 0.05 ）. Conclusion Oxymatrine combined with vaccae in the treatment of chronic B hepatitis can improve effectively normalization rate of ALT and negative conversion rate of HHV DNA and HbeAg.
出处
《新乡医学院学报》
CAS
2005年第5期497-498,共2页
Journal of Xinxiang Medical University
关键词
苦参素
母牛分枝杆菌菌苗
慢性乙型肝炎
Oxymatrine
cow ramification rod bacteria immunity seedling
chronic B hepatitis
