摘要
应用雄性小鼠生殖细胞非程序ＤＮＡ合成（ＵＤＳ）试验方法，动态地观察了人参二醇组皂甙（ＰＤＳ）对甲基磺酸甲酯（ＭＭＳ）所诱发ＵＤＳ的抑制作用。结果表明，在ｉｐＭＭＳ（７５ｍｇ／ｋｇ）同时或提前１～５ｈ将ＰＤＳ（２４０ｍｇ／ｋｇ）ｉｐ小鼠，可明显抑制小鼠精子ＵＤＳ，而在ＭＭＳ给予后ｉｐＰＤＳ则对ＭＭＳ诱发的ＵＤＳ无明显影响。提示ＰＤＳ可预防ＭＭＳ对遗传物质的损伤作用。
Methyl methanesulfonate(MMS,75 mg/kg ip )-induced unscheduled DNA synthe-sis(UDS) inhibited significantly in the spermatozoa of mice with ip panaxadiol saponin(PDS,240mg/kg) at 0～5 h prior to ip MMS. PDS ip at 1～5 h after injection of MMS did not affect UDSinduced by MMS. These results indicate that PDS may protect genetic materials from damagecaused by MMS.
出处
《中国药学杂志》
CSCD
北大核心
1995年第2期69-81,共13页
Chinese Pharmaceutical Journal
关键词
人参
二醇组皂甙
甲基磺酸甲酯
精子
DNA
合成
panaxadiol saponin
methyl methanesulfonate
spermatozoa
unscheduled DNAsynthesis
DNA repair
