摘要
杂种犬43只,参照体重随机分为失血性休克人参预治疗组(HSG),失血性休克地塞米松预治疗组(HSD),各14只,其余15只为失血性休克组(HS)组。HSG组静脉注射人参二醇组皂甙溶液25mg/kg。HSD组肌注地塞米松1mg/kg,均于放血前1h给药。经颈动脉放血使平均动脉压降至5.3kPa,观察5h。结果表明,5h存活率,HSG组为92.9％,HSD组为76.9％(其中2只死于胃肠道弥漫性出血),HS组为66.7％;血浆血管紧张素Ⅱ(AⅡ)含量的变化显示,地塞米松和人参二醇组皂甙抑制失血后AⅡ含量的增高;血清去甲肾上腺素(NE)的测定结果表明,人参二醇组皂武和地塞米松可阻止失血性休克时血清NE含量的持续增高。
Forty-three mongrel dogs subjected to hemorrhagic hypotension at a mean arterial pressure of 5.3 kPa for 5 hours were randomly divided into one group (n = 14) pretreated with 25mg/kg of panaxadiol saponins (HSG) , one group (n = 14) pretreated with 1 mg/kg of dexamethasone (HSD) and one group (n-15) without any pretreatment (HS) .The results indicated that the survival rate at the 5th hour in HSG, HSD and HS groups were. 92.9%, 76.9% and66.7% respectively, and the usual increases in serum angiotension II andnorepiuephrine during the hemmorhagic shock were inhibited by panaxadiolsaponins and dexamethasone.
出处
《白求恩医科大学学报》
CSCD
1990年第3期244-244,共1页
Journal of Norman Bethune University of Medical Science
关键词
人参
皂甙
休克
血管紧张素
Hemorrhagic shock Dogs Panaxadiol saponins Dexamethasone Norepinephrine Angiotension II
