摘要
从体内、体外研究了抗Ｔｈｙ－１单克隆抗体（ＭｃＡｂ）的免疫抑制作用。结果表明：（１）体外抗Ｔｈｙ－１ＭｃＡｂ在补体参与下能够杀伤小鼠胸腺细胞，无补体时能抑制ＣｏｎＡ诱导的Ｔ淋巴细胞增殖反应；（２）在体内，可以抑制小鼠脾细胞对ＣｏｎＡ和ＰＨＡ诱导的Ｔ淋巴细胞增殖、但不影响ＬＰＳ诱导的Ｂ淋巴细胞增殖反应。结果说明：抗Ｔｈｙ－１ＭｃＡｂ的免疫抑制作用可能包括补体依赖性细胞毒作用和通过Ｔｈｙ－１分子对Ｔ淋巴细胞功能的抑制。
his paper
was designed to investigate the immunosuppressive activities of
anti-Thy-1 mon-oclonal antibody (McAb ) in vitro and in vivo. The
results showed: (1) anti-thy-1 McAb withcomplement can destrony the
thymocytes of C57BL/6 and 615 mice in vitro ,and inhibit the
pro-liferation of murine spleen cells stimulated by ConA mitogen
without complement; (2)the mito-genic response of spleen cells from
C57BL/6 mice administrated with in vivo to ConA and PHAis obviously
inhibited, but the response to LPS is not affected. These result
suggest that themechanisms of the immunosuppression and
anti-rejection response may be involved in the deple-tion of T
lymphocytes from the mice and the inhibition of T lymphocyte function
with indepen-danc on complement.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第3期139-141,共3页
Chinese Journal of Immunology
关键词
免疫抑制
T淋巴细胞
单克隆抗体
Anti-thy-1 McAb
Immunosuppression Lymphocyte proliferation
