摘要
以透明质酸（ＨＡ）和层粘素（ＬＮ）为非胶原性间质成份的代表，观察其对大鼠培养肝实质细胞和人胎肝细胞￣３Ｈ－胸腺嘧啶核苷（￣３Ｈ－ＴｄＲ）和￣３Ｈ－脯氨酸（￣３Ｈ－Ｐｒｏ）掺入的影响。结果表明，正常血清浓度的ＨＡ和ＬＮ对肝细胞无明显的影响，高浓度则显著抑制￣３Ｈ－ＴｄＲ及￣３Ｈ－Ｐｒｏ的掺入，但抑制程度和剂量递增无显著相关性。
Liver parenchymal cells from rat were isolated and human fetal livercells( HuL-1)were cultured.Tritiated proline and thymide were used to examine colla-gen formation and cell proliferation. The results demonstrated that physiological con-centrations of hyaluronate(HA ) and laminin(LN )had no effects on cell proliferation,but slightly inhibited collagen production, On the other hand high concentrations ofHA and LN significantly inhibited both rat hepatocytes and HuL-1 cells proliferationand also collagen synthesis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1995年第1期109-112,共4页
Chinese Journal of Pathophysiology
