摘要
选择血清血栓素(TXB_2)和组织Even蓝岔量为指标,观察大鼠右半结肠缺血再灌注损伤及5-氨基水杨酸(5-ASA)的治疗作用。结果显示,缺血再灌注后结肠组织Even蓝含量及血清中TXB_2的浓度明显增高。结肠内灌注5-ASA后,Even蓝含量和TXB_2浓度下降,以30mg/kg的剂量最明显。以上结果提示,足够剂量的5-ASA有防治结肠缺血再灌注损伤的作用。其作用机理同5-ASA减少氧自由基形成有关。
The serum thromboxin B2(TXB2) and Even' s blue in the tissue were selected as indexes. The injury induced by ischemia and reperfusion in the proximal colon and the therapeutic action of 5-aminosalicylic acid(5-ASA) were observed in rats. The results showed that the content of Even' s blue in proximal colon and the concentration of serum TXB2 were significantly increased after ischemia and reperfusion. If 5-ASA in dosage of 30mg/kg was infused into the colon,the content of Even' s blue and TXB2 concentration would be significantly decreased. It was suggested that 5-ASA possessed protective and therapeutic actions on injured colon induced by ischemia and reperfusion, and the mechanism was in relation to the decreased production of oxygen free radicals.
出处
《天津医药》
CAS
1995年第2期97-99,共3页
Tianjin Medical Journal
关键词
氨基水杨酸
氧自由基
结肠缺血
再灌注损伤
ischemia/reperfusion injury rat oxygen free radicals inflammatory bowel disease
