摘要
目的:探讨肺结核患者口服对氨基水杨酸异烟肼片时对氨基水杨酸对利福平血药峰浓度的影响。方法:采取同一患者自身前后对照,同时服用对氨基水杨酸异烟肼片和利福平胶囊为观察组,同时服用异烟肼片和利福平胶囊为对照组,分别检测2组异烟肼和利福平的血药峰浓度,观察对氨基水杨酸对利福平血药峰浓度的影响。结果:口服异烟肼片和利福平胶囊后1.5h异烟肼和利福平平均血药浓度分别为(4.88±2.32)μg·mL-1和(6.49±3.40)μg·mL-1,而口服对氨基水杨酸异烟肼片和利福平胶囊后1.5h两者平均血药浓度分别为(2.62±2.34)μg·mL-1和(5.84±2.74)μg·mL-1。2组利福平血药峰浓度比较,差异无统计学意义(P>0.05);2组异烟肼血药峰浓度比较,差异有统计学意义(P<0.05)。结论:对氨基水杨酸异烟肼片中的对氨基水杨酸未对利福平血药峰浓度产生明显影响。
OBJECTIVE：To investigate the effects of aminosalicylic acid on peak blood concentration of rifampicin in pulmonary tuberculosis patients receiving Isoniazid aminosalicylate tablets.METHODS：Taking the same patients before-after controlled method,observation group received Isoniazid aminosalicylate tablets and Rifampicin capsules,and control group received Isoniazid tablets and Rifampicin capsules.The peak blood concentrations of isoniazid and rifampicin were detected in 2 groups.The effects of Isoniazid aminosalicylate tablets on peak blood concentration of rifampicin were observed.RESULTS：The mean blood concentrations of isoniazid and rifampicin after taking drugs for 1.5 hours were（4.88±2.32）μg·mL-1 and（6.49±3.40）μg·mL-1 in control group,（2.62±2.34）μg·mL-1 and（5.84±2.74）μg·mL-1 in observation group.There was no significant difference in peak blood concentration of rifampicin between two groups（P0.05）,and there was significant difference in peak blood concentration of isoniazid between two groups（P0.05）.CONCLUSION：Aminosalicylic acid of Isoniazid aminosalicylate tablets has no obvious effect on peak blood concentration of rifampicin.
出处
《中国药房》
CAS
CSCD
2012年第30期2839-2841,共3页
China Pharmacy
关键词
肺结核
抗结核药物
血药峰浓度
氨基水杨酸异烟肼片
对氨基水杨酸
利福平
Tuberculosis
Antituberculous drugs
Peak blood concentration
Isoniazid aminosalicylate tablets
Aminosalicylic acid
Rifampicin
