摘要
本文应用体外培养方法观察了不同浓度的替硝唑（ＴＮＺ）对阴道毛滴虫的作用。ＴＮＺ浓度为１．２５μｇ／ｍｌ培养４８ｈ或２．５０μｇ／ｍｌ培养６ｈ对虫体有抑制作用；ＴＮＺ浓度为５．００μｇ／ｍｌ培养２４ｈ，１０．０－２０．００μｇ／ｍｌ培养６ｈ均可使虫体１００％致死。与甲硝唑相比，效果相似。提示ＴＮＺ杀阴道毛滴虫效果好。
The trichomonacidal activity of tinidazole (TNZ) was observed in vitro cultivation of T.vaginalis (1×105-2×105 protozoa/tubule) with 5 different TNZ concentrations. After 24-hour incubation with TNZ, the inhibitive concentrations were 1. 25-2. 50μg/ml, while 100% lethal concentration was 5. 00μg/ml after 24-hour or 10. 00-20. 00μg/ml after 6-hour incubation. In comparison with metronidazole, trichomonacidal effect of both drugs were similar. The studies showed that T. vaginalis was highly sensitive to TNZ in vitro.
出处
《实用寄生虫病杂志》
1995年第3期120-121,共2页
Journal of Practical Parasitic Diseases
关键词
替硝唑
阴道毛滴虫
抗滴虫药
药理学
Tinidazole, Trichomonas vag inalis, in vitro cultivation, metronidazole
