摘要
探讨急性腹泻病血浆胃动素与胃泌素的变化及其与症状的关系。方法急性腹泻患儿３８例（腹泻组），男１７例，女２１例，１０例健康儿童为对照组。用放射免疫分析法测定其血浆胃动素及胃泌素。结果对照组餐前及餐后胃功素水平分别为１９８．８９±３７．７９和２６４．５３±４６．６７ｎｇ／Ｌ，胃泌素水平分别为６６．６０±１５．８９和１１３．１０±２９．６４ｎｇ／Ｌ。治疗前腹泻组餐前及餐后胃动素水平分别为３９０．２７±１４８．６１、５１４．８５±１７２．４０ｎｇ／Ｌ，胃泌素分别为７８．６１±２０．６７、１２４．０５±３２．１８ｎｇ／Ｌ，治疗后腹泻组则分别为２０５．４２±１３５．４０、３５９．８７±１３３．９２、６９．５９±２６．０２、１０９．７９±３７．２７ｎｇ／Ｌ。正常对照组胃动素餐前与餐后相比有极显著性差异（Ｐ＜０．００１），胃泌素水平餐前与餐后相比有显著性差异（Ｐ＜０．０５）。治疗前腹泻组餐前与餐后胃动素水平、胃泌素水平均有极显著性差异（Ｐ＜０．００１），腹泻组与对照组胃动素、胄泌素水平有显著性差异，治疗前腹泻组与治疗后腹泻组胃动素水平有显著性差异（Ｐ＜０．０５）。结论急性腹泻患儿血浆胃功素水平显著高于正常对照组，症状缓解后?
Objective To search for the changes of serum motilin and gastrin levels and the relationship between the levels and symptom in children with acute diarrheal disease.Methods There were 38 children with acute diarrheal disease(male 17,female 21)in acute diarrheal disease group(group AD),10 health children in control group.The serum motilin and gastrin levels were determined by RIA.Resulls The levels of motilin before and dafter meal are 198.89 ±37.79 and 264.53±46.67ng/L respectively,and that of gastrin are 66.60±15.89 and 113.10±29.64ng/L respectively in control group.The levels of motilin before and after meal are 390.27 ±148.61 and 514.85±172.40ng/L,and that of gastrin are 78.61 ±20.67,1 24.05 ±32. 18ng/L respectively in group AD before tre ment.They are 265.42 ±135.40,359.87±133.92,69.59 ±26.02,109.79 ±37.27ng/L respectively in group AD after treatment.There are very significant difference between the levels of motilin before and after meal in control group(p<0.001),There are significant difference between the levels of gastrin before and after meal in control group(P<0.05).There are very significant difference between the levels of motilin and gastrin before and after meal in group AD before treatment(P<0. 001).There are significant difference of the levels of motilin and gastrin between the control group and AD group.There are significant defference of the motilin levels between before and after group AD(P<9.05).Conclusions The level of serum motilin in groupAD is obviously higher than that in control group,and if is decreased after symptom remission. The gastrin level is increased only in children with acute severe diarrhea.
出处
《实用儿科临床杂志》
CAS
CSCD
1995年第4期193-195,共3页
Journal of Applied Clinical Pediatrics
