摘要
目的探讨FDG-PET对非小细胞肺癌分期的影响,进一步评价TNM分期和正确的治疗措施。方法经病理证实的NSCLC 49例,以纵隔淋巴结FDG摄取增高及SUV≥2.5作为阳性判断标准,进行纵隔淋巴结分期,分别比较PET和病理结果的一致性及其特点;比较PET和CT的各自优缺点及其互补性。结果经以上比较PET在评价肺癌分期方面明显优于CT,可弥补CT的不足。PET检查的实施部分重新评估TNM分期,选择恰当的治疗措施。结论PET的应用可以弥补CT的不足,对选择合适的治疗措施有重要指导意义。
Objective To evaluate the diagnostic significance of FDG-PET in preoperative mediastinal lymph node staging for non-small cell lung cancer （NSCLC）. Methods Whole body FDG-PET imaging was performed in 49 patients with NSCLC. All patients received thoracic CT examination 2 weeks before FDG-PET scan or 1 week after FDG-PET scan. After intravenous administration of ^18F -FDG （5.55 × 10^6 Bq/kg） , PET scan was performed in 3 to 7 bed positions with 2 dimension and OSEM reconstruction. For quantitative evaluation, a region of interest （ROI） was placed over theme mediastinal lymph node which had abnormal uptake of radiation activity, then the standardized uptake value （SUV） were calculated. If SUV ≥2.5 or uptake activity was higher than the blood pool of mediastinal on the basis of visual inspection, it was considered to be positive. Results The sensitivity and specificity of PET were 100% and 95% , respectively. The positive lymph nodes diagnosed by PET correctly corresponded to pathological results. PET changed the clinical staging of 12 patients. Conclusion PET is an effective modality for accurate mediastinal lymph node staging in patients with NSCLC and valuable for determining clinical treatment.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第15期1576-1578,共3页
Journal of Third Military Medical University
