摘要
以RTPCR方法检测胰岛素抵抗(IR)大鼠及2型糖尿病(DM)大鼠肝脏肝细胞核因子(HNF)4α及HNF1αmRNA表达水平。结果显示肝脏HNF4α及HNF1αmRNA表达量在IR大鼠显著低于正常对照大鼠,在DM大鼠则进一步降低。两基因表达改变可能与IR及2型DM有关。
The expressions of HNF-4α and HNF-1α gene were assayed by RT-PCR in the livers of insulin-resistant rats and type 2 diabetic rats. mRNA levels of HNF-4α and HNF-1α in insulin-resistant rats were lower than those in control rats, and these levels were further decreased in diabetic rats. Changes in expressions of these 2 genes seem to be associated with type 2 diabetes mellitus.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2005年第4期325-326,共2页
Chinese Journal of Endocrinology and Metabolism
