摘要
目的探讨白细胞介素6、8(IL-6、IL-8)在慢性肾衰患者的表达意义。方法应用酶联免疫吸附双抗夹心法(ELISA)测定25例慢性肾炎,25例慢性肾衰尿毒症非血透和25例维持性血透患者的血清IL-6、IL-8水平,并设25例健康对照组。结果慢性肾炎、尿毒症非透析组及血透组血清IL-6、IL-8水平均明显高于对照组(P<0.01),维持性血透组IL-8明显低于非血透组(P<0.05),而IL-6无显著差异(P>0.05)。结论IL-8,IL-6对慢性肾炎、肾衰尿毒症非血透与维持性血透患者的疗效观察和急性炎症反应期的监测具有重要价值。
Objective To search the expressive and significance of serum IL-6 and IL-8 in patiens with chronic renal failure. Methods Enzyme linked immunosorbent assay （ELISA） was used to detect the serum IL-6 and IL-8 from 25 cases of chronic nephritis, 25 cases of renal failure without hemodialysis, 25 cases of renal failure received maintenance hemodialysis and 25 healthy persons. Results The serum levels of IL-6 and IL-8 in patiens with chronic nephritis or renal failure were significantly highcr than those in control group（P〈0.01）. The serum IL-8 level in patiens with renal failure received maintenance hemodialysis was significantly lower than that of the group without hemodialysis （P〈0.05）, but the serum IL-6 level was not significance between them（P〉0.05）. Conclusions These data suggests that serum levels of IL-6 and IL-8 have important value to observating curatiue effect and monitoring acute inflammatory reaction in patients with chronic nephritis and renal failure.
出处
《江西医学检验》
2005年第4期303-304,共2页
Jiangxi Journal of Medical Laboratory Sciences
