摘要
①目的探讨不稳定型心绞痛病人血清载脂蛋白A、B(apoA、apoB)及相关脂类,抗凝、纤溶指标与冠状动脉病变的关系.②方法选择行冠状动脉造影病人173例,其中不稳定型心绞痛病人136例,均经冠状动脉造影证实至少一支冠状动脉狭窄＞70%,其中单支病变65例,双支或多支病变71例,冠状动脉造影正常者(对照组)37例.采空腹静脉血2 mL检测生化全套.③结果对照组、单支病变组、多支病变组apoB、三酰甘油(TG)、总胆固醇(TC)、抗凝血酶Ⅲ、纤维结合蛋白水平及apoB/apoA比较有显著统计学意义(F＝3.70～6.08,P＜0.05);而apoA1、纤溶酶原各组间差异无显著性(F＝0.09、2.78,P＞0.05).apoB、TG、纤溶酶原、纤维结合蛋白含量及apoB/apoA与冠状动脉积分呈正相关(r＝0.502～0.605,P＜0.05),apoA1与冠状动脉积分呈负相关(r＝-0.601,P＜0.01).④结论apoB、apoB/apoA的升高是冠心病的危险因素,并与冠状动脉病变的严重程度有关.
Objective To investigate the relationship between coronary arteriopathy and serum relative markers including apoA, apoB, other related lipids, antithrombin Ⅲ, profibrinolysin and fibronectin in unstable angina patients. Methods One hundred and seventy-three patients were divided into unstable angina group （n=136） and control group （n=37） by coronary arteriography. The unstable angina patients who had one or more coronary obstructions greater than 70% were sub-divided into a singlevascular lesion group （n=65） and a multiple vascular lesion group （n=71）. All blood samples were taken after fasting and then serum relative markers were determined. Results There were significant differences in apoB，TG, TC, AntithrombinⅢ, fibronectin and apoB/apoA among the three groups （F=3.70-6.08,P〈0.05） but not in apoA1 and profibrinolysin （F=0.09, 2.78；P〉0.05）. ApoB, apoB/apoA, TG, profibrinolysin and fibronectin were positively correlated with coronary artery stenosis scores（r=0. 502-0.605, P〈0.05） while apoA1 was negatively correlated （r=-0.601, P〈0.01）. Conclusion The increase of apoB and apoB/apoA is one of the risk factors of CHD, and is related to the severity of CHD.
出处
《青岛大学医学院学报》
CAS
2005年第2期121-122,124,共3页
Acta Academiae Medicinae Qingdao Universitatis
