摘要
目的:探讨无抽搐电休克(MECT)治疗对抑郁症病人睡眠脑电活动的影响。方法:应用多导睡眠图(PSG)对12例男性首发抑郁症病人在MECT治疗前后进行整夜PSG记录,观察MECT治疗前后PSG的变化。结果:与正常对照组比较,病人组睡眠总时间减少、睡眠潜伏期延迟、觉醒增加、快动眼睡眠(REM)时间增多、REM潜伏期缩短、S1和S2增加以及慢波睡眠减少。病人组经过MECT治疗后PSG显示睡眠总时间增加[治疗前:(342±s51)min,治疗后:(437±25)min,t值11.840,P<0.01],睡眠潜伏期缩短[治疗前:(68±12)min,治疗后:(56±7)min,t值4.249,P<0.01],觉醒时间减少[治疗前:(163±43)min,治疗后:(30±7)min,t值10.409,P<0.01],REM睡眠时间减少[治疗前:(164±19)min,治疗后:(120±5)min,t值9.333,P<0.01],S1减少[治疗前:(46±15)min,治疗后:(39±11)min,t值5.071,P<0.01],慢波睡眠增加[治疗前:(34±19)min,治疗后:(99±7)min,t值-13.146,P<0.01]。REM潜伏期和S2未见明显变化(P>0.05)。结论:MECT有改善睡眠的作用。这可能是MECT起到治疗抑郁症的重要机制之一。
AIM： To investigate the effect of magnified electroconvulsive therapy （MECT） on poly somnography （PSG） in patients with major depression. METHODS： The PSG were recorded all over night from 12 male patients with major depression before and after MECT, using Neurofax-1518K （Nihon Kohden）sleep instrument. RESULTS： The depression patients showed inclusions of reduced total sleep time,delayed sleep latency, increased awakening time, increased rapid eyemovement sleep （REM）, shortened REM latency, increased S1 and S2, and decreased slow wave sleep. After MECT, depression patients presented with improvement on total sleep time （before MECT （342 ±s 51） min vs after MECT （437 ±25）min, t = 11. 840, P 〈 0.01 ）, shortened sleep latency（68±12 vs 56±7, t =4.249, P〈0.01） , reduced awakening time （163 ±43 vs 30±7, t = 10.409, P 〈0.01）, reduced REM time （164 ± 19 vs 120±5, t =9.333, P〈0.01）, reduced S1 （46 ±15 vs 39 ±11, t=5.071, P 〈0.01）, and increased slow wave sleep time （34±19 vs 99±7, t = -13.146, P〈0.01）.No significant differences were found between REM latency and S2 before and after MECT. CONCLUSION： MECT is useful to promote sleep, which might be one of the important mechanisms for treating depression.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2005年第8期624-627,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
上海第二医科大学自然科学基金项目(03XJ21106)
上海第二医科大学博士点基金项目(BXJ0306)
关键词
抑郁症
电惊厥疗法
多导睡眠描记术
无抽搐电休克治疗
快动眼睡眠
慢波睡眠
depression
electroconvulsive therapy
polysomnography
magnified electroconvulsive therapy
rapid eyemovement sleep
slow wave sleep
