摘要
本实验采用雾化吸入平阳霉素的方法，复制小白鼠肺纤维化的模型。结果表明，吸入后１５天时，肺组织形态学呈３级肺泡炎改变，肺组织脂质过氧化物（ＬＰＯ）含量显著升高（Ｐ＜０．００１）；吸入后３０天时，肺组织形态学呈１级肺纤维化改变。
This experiment studied the model of pulmonary fibrosis in mouse by aerosol inhalation of pingyangmycin.The results showed that after 15 days of inhalation, the morphological changes appeared as three grade alveolitis in thd lung,and the level of lipid peroxide (LPO)in the lung also increased remarkably (P<0. 001),and that after 30 days of inhalation the change of one grade pulmonary fibrosis was observed.
出处
《哈尔滨医科大学学报》
CAS
1995年第1期4-5,共2页
Journal of Harbin Medical University
关键词
肺纤维化
平阳霉素
过氧化脂质
Pulmonary fibrosis
Pingyangmycin
Lipid peroxide
