摘要
异种脱钙骨基质(HDBM)及其释放系统(DS)的实验研究旨在提高HDBM诱导成骨的成功率。实验用小公牛长骨干制成HDBM,加DS-CaCl_2或CaSO_4+Na_2HPO_4+KH_2PO_4移植到家兔尺骨1.5cm缺损内。经观察,X-线照片的骨钙化影出现率除CaCl_2组16、20周外可达100％,组织学为100％的新生骨形成。作者认为:HDBM及DS诱导成骨好的原因是CaCl_2或CaSO_4中Ca^(++)与Na_2HPO_4、KH_2PO_4可促进HDBM中BMP加速释放的结果。
This experiment is- carried by using the long bone shafts of ox prepared for the heterogenous decalcified bone matrix(HDBM) and adding the delivery system (CaCl2 or CaSO4+Na2HPO4+KH2PO4), implanted into the 1.5 cm defect of the rabbit ulna. Except the CaCl2 group in 16 w and 20 w all the implanted bone matrix shows 100% calcified shadows and the new bone formation is 100% identified histologically. The author belived that the cause of the excellent bone induction osteogenesis of HDBM and its DS in CaCl2 or CaSo4, was the results of Ca++ with Na2HPO4 and KH2PO4 to enhanced and accelerated BMP dilirery in HDBM.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1989年第5期371-374,共4页
Journal of Third Military Medical University
关键词
诱导成骨
脱钙骨基质
释放系统
induction osteogenic
heterogenic, decalcified bone matrix
dilivery system
