康泉与枢复宁分别联合胃复安控制化疗引起的恶心呕吐疗效的比较被引量：1

Comparison of effects of granisetron and ondansetron combined with metoclopramide respectively to control nausea and vomiting induced by chmotherapy

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摘要对应用顺铂、阿霉素为主进行化疗的６６例恶性肿瘤患者，分别采用康泉（３２例）和枢复宁（３４例）联合胃复安、苯海拉明作为止吐剂控制恶心呕吐反应，结果发现康泉组对急性呕吐反应的控制明显优于枢复宁组。第１天控制呕吐的有效率（ＣＲ＋ＰＲ）分别为９６％和８０％，控制恶心的有效率（ＣＲ＋ＰＲ）分别为９４％和７７％，两组比较Ｐ＜０．０５。两组对延缓期（２～５天）呕吐反应的疗效无统计学差别。两组副反应均轻微。本文提示单剂量康泉或枢复宁联合胃复安、苯海拉明控制化疗引起的急慢性呕吐反应疗效满意，而对重度急性呕吐反应的控制单剂量康泉优于单剂量枢复宁。 patients with malignant tumor were treated by cisplatin and adriamycin combined with scheme of chemotherapy. The patients randomly received Granisetron(32 cases) or ondansetron(34 cases) combined with metoclopramide and diphenhydramine respectively to control nausea and vomiting induced by chemotherapy. The results showed that a single dose of Granisetron was superior to a single dose of ondansetron in controlling acute nausea (CR+ PR: 94% and 77%, respectively, P<0.05) and vomiting(CR+PR: 96% and 80%, respectively, P<0.05). Control of delayed emesis was comparable in the two grops. No patients had serious side effects. This study suggest Granisetron or ondansetron combined with metoclopramide was effective in the control of nausea and vomiting induced by chemotherapy. A single dose of Granisetron was better than a single dose of ondansetron for controlling acute serious emesis.