摘要
本研究验证了国产新型强心药CI-914对离体豚鼠心房的作用,与异丙肾上腺素(ISO)和氨茶碱(AP)作比较。在以恒定电刺激驱动的左心房上观察药物的正性肌力作用;在自发跳动的右心房上观测药物的正性频率作用,结果表明(1)CI-914的正性肌力作用类似ISO,在蓄积给药条件下呈现较好的量-效关系,而AP的正性肌力作用较弱;(2)ISO和AP均有非常显著的正性频率作用;CI-914虽也可使心房收缩率增加,但并不显著;(3)在离体豚鼠左心房上CI-914使细胞外Ca^(2+)浓度-肌力效应曲线左移,提示CI-914对Ca^(2+)内流似有促进作用。
Cardiotonic effect of CI-914 (Imazodan), a PDE-inhibitor, was studied on isolated guinea pig atria and compared with that of isoprenaline(ISO)and amino-phylline (AP).The electrically-paced left atria were used to determine their inotroplc effects, wh:;le the spontaneously beating right atria were used to determine their chronotropic ones.Both ISO and CI-914 showed a significant concentration-dependent positive inotropic effect with similar maximal effects(efficacy), though their potencies were quite different(the pD2 of the former was 7.7 and the latter, 4.7).AP also showed a positive inotropic effect but insignificantly.Both ISO and AP showed a significant concentration-depenednt positive chronotropic effect, and CI-914 tended also to increase heart rate but insignificantly.The extracellular calcium concentration-positive inotropic effect curve could be shifted to the left by CI-914.It is suggested that CI-914 could promote calcium influx through calcium-channels, which is probably one of the mechanisms responsible for the cardiotonic action of CI-914.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第1期49-52,共4页
Academic Journal of Second Military Medical University
关键词
强心药
CI-914
离体心房
cardiotonic agent
CI-914
imazodan
isoprenaline
aminophylline
guinea pig
isolated atria
