摘要
采用荧光激素结合法，分别对３０例过期妊娠（过期妊娠组）和２７例足月妊娠妇女（对照组）有关的靶组织（胎盘、胎膜、子宫胎盘床和子宫下段肌层）的雌激素受体（ＥＲ）和孕激素受体（ＰＲ）进行了定性和定量分析。结果：过期妊娠组子宫胎盘床及胎膜ＥＲ水平较对照组明显减少，而ＰＲ却无明显差异；过期妊娠组各靶组织内ＥＲ与ＰＲ的比值（ＥＲ／ＰＲ）都明显低于对照组；各靶组织ＥＲ与ＰＲ水平呈明显的正相关；有宫缩者子宫下段肌层ＥＲ／ＰＲ值明显高于无宫缩者。提示：过期妊娠的发生与ＥＲ水平下降和ＰＲ水平上升有关，而子宫收缩则与ＥＲ水平上升和ＰＲ水平下降有关。
bjective To reveal the relation between the changes of the estrogen receptor(ER)and pro-gesterone receptor(PR)levels in the target tissues and the duration of pregnancy.Methods The method combining fluorescence with hormones and polyspectrum-data system were used to qualitatively and quantitatively assay the estrogen and progesterone receptor concentra-tions in the placenta, fetal membrane, uteroplacental bed and uterine myometrium in 30 cases with prolonged pregnancy and 27 cases of term pregnancy.Results ER concentrations in the uteroplacental bed and fetal membrane of the prolonged preg-nancy group were markedly lower than that in the term group; ER/PR values in every target tissues of the prolonged pregnancy were much less than that in the term group;There is a positive relation-ship between ER and PR levels in all target tissues evidently; and ER/PR value in the lower segment of the uterine myometrium in the group with uterine contraction were significantly higher than that of group without uterine contraction.Conclusions The mechanisms of both prolonged pregnancy and onset of labour were revealed partly in this study; The cause of prolonged pregnancy is relatively concerned with the decline of ER levels and the ascent of the PR concentrations in the target tissues. Also the uterine contraction is in-duced byt he increase of E R and decrease of P R.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1995年第9期536-538,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
过期妊娠
受体
雌激素
孕酮
胎盘
胎膜
Pregnancy,prolonged Receptor,estrogen Receptors,progesterone Placenta Fetal membrance
