摘要
运用放射免疫竞争性蛋白结合法，测定１８例缺铁性贫血（ｉｒｏｎｄｅｆｉｃｉｅｎｃｙａｎｅｍｉａ，ＩＤＡ）患儿单纯铁剂治疗前后，及１１名正常对照儿童血清２５－羟胆骨化醇［２５－（ＯＨ）Ｄ＿３］浓度。结果表明，缺铁可能削弱肠道对维生素Ｄ的吸收，降低血清中２５－（ＯＨ）Ｄ＿３浓度，从而导致体内维生素Ｄ缺乏。说明补充铁剂能促进维生素Ｄ在肠道的吸收，提高血清２５－（ＯＨ）Ｄ＿３水平，改善维生素Ｄ缺乏状况。
erum 25-hydroxycholecalciferol [ 25-(OH )D_3]concentration was measured via competitive radioim-mune assay in 18 children with iron deficiency anemia(IDA)and 11 normal controls.The mean value ofserum 25-(OH)D_3 in 18 IDA children was 14.8±1.2ng/ml, which was significantly lower thanthat in 11 normal children whose mean value was27.9±1.1 ng/ml. Eleven out of 18 IDA childrenwithout clinical symptoms and signs of richets, whoseserum 25-(OH)D_3 concentration(mean value 11.5±0.4ng/ml) was below the normal range, were consid-ered suffering from subclinical vitamin D deficiency. After treatment,the mean serum 25-(OH) D_3 concen-tration in 18 IDA children was 24. 8±0.9ng/ml, andthat of 11 IDA children reaching the level of subclinicalvitamin D deficiency also rose to normal range(meanvalue 23.5±1.0ng/ml).Our data suggest that irondeficiency may impair intestinal absorption of vitaminD, which may lead to the development of vitamin Ddeficiency and that iron supplementation may alter thestatus of vitamin D deficiency.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1995年第6期355-337,共1页
Chinese Journal of Pediatrics
