摘要
目的:调查并评价乙型肝炎患者的生活质量,分析其主要影响因素。方法:选择2001-08/2004-12在中国医科大学附属第一医院感染科住院的慢性乙型肝炎患者200例作为病例组,均自愿接受调查。同期选择200例健康人为对照组。记录病例组的一般资料及临床资料,采用生活质量量表简短36条目问卷中国版对两组调查对作生活质量评分并进行比较。该问卷由8个领域共36个条款组成,即躯体功能10条,躯体角色4条,机体疼痛2条,总健康状况5条,机体活力4条,社会功能2条,情绪角色3条和心理卫生5条,第36个条款是指与1年前相比患者总的健康状况改变情况。根据各个领域的不同评分(0为最低分,100为最高分)可以评价躯体和心理两个状态的总体状况,分值越低,生活质量越差。将总评分作为因变量,对影响生活质量的因素进行单因素分析和多因素逐步回归分析,筛选主要影响因素。结果:进入结果分析病例组和对照组均保持为200例。①生活质量量表简短36条目问卷各领域得分比较:病例组问卷总评分及躯体角色、总健康状况、机体活力、社会功能、情绪角色和心理卫生评分均显著低于对照组犤(71±30,52±16,50±22,55±28,28±34,45±18,56±17);(79±26,80±23,82±28,84±21,84±31,79±19,79±23),(t=2.983～4.257,P<0.01)犦。②乙型肝炎患者生活质量影响因素的多因素逐步回归分析结果:临床分型、乏力、黄疸、血清转氨酶与总胆红素、血浆白蛋白以及乙肝病毒脱氧核糖核酸为主要影响因素(P<0.05～0.01)。结论:慢性乙型肝炎患者的生活质量明显下降,及时控制病情进展、缩短病程、针对病情进行有效的干预以减轻躯体症状,使转氨酶水平降低,有利于改善患者的生活质量。
AIM: To investigate and evaluate the quality of life ( QOL)in patients with chronic severe hepatitis and analyze the factors associated with the QQL.METHODS: 200 inpatients with chronic severe hepatitis B were enrolled as case group from the Department of Infection, the First Affiliated Hospital of China Medical University between August 2001 and December 2004. Meanwhile, 200 healthy persons were selected as controls. General data and clinical data of 200 patients were recorded in comparison with those of 200 healthy subjects through a 36-item short form (SF-36), Chinese version. SF-36 consisted of 8 aspects, totally 36 items, namely, 10 items on somatic function, 4 items on somatic role, 2 items on bodily pain, 5 items on general health status, 4 items on vitality, 2 items on social function, 3 items on emotional role, and 5 items on mental health, and the 36th item is the changes in health status as compared with that before one year. Scores on different items could be used to evaluate patients'somatic and mental status, with 0 score as the lowest and 100 score as the highest. The lower the scores, the poorer the QOL. Univariate and multivariate stepwise regression analysis were performed to assess the factors related to QOL with the total scores as dependent variables, and screen the main factors. RESULTS: All the 400 subjects were involved in the result analysis. ①Scores on SF-36: Scores on total score, somatic role, general health status, vitality, social function, emotional role and mental health were significantly lower in the control group than in the case group (71±30, 52±16, 50±22, 55±28, 28±34, 45±18, 56±17; 79±26, 80±23, 82±28, 84±21, 84±31, 79±19, 79±23, t=2.983-4.257, P < 0.01). ② Multivariate stepwise regression analysis on the factors related to QOL of patients with hepatitis B: The main factors included clinical typing, inertia, jaundice, serum transaminase, total bilirubin, serum albumin, serum bilirubin and hepatitis B virus DNA (P < 0.05-0.01).CONCLUSION: A significant decrea
出处
《中国临床康复》
CSCD
北大核心
2005年第23期6-7,共2页
Chinese Journal of Clinical Rehabilitation
