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成人与少儿乙型肝炎病毒相关性肾炎的临床病理分析 被引量:3

Clinical pathogenic analysis of glomerulonephritis associated with hepatitis B in adult and children
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摘要 目的比较成人与少儿HBV-GN的HBV抗原、免疫荧光、组化及病理分型,探讨二者之间的异同。方法将经肾活检确诊为HBV-GN患者按年龄分为成人组与少儿组,分析二组的临床、病理特点。结果临床表现成人组以蛋白尿(19例)和肾病综合征(17例)为主,少儿组则以肾病综合征为主。当血清中HBsAg、HBcAb阳性时,少儿组的病理类型以膜性肾病(MN)和系膜增生型肾小球肾炎(MsPGN)为主(58·8%),其比例明显高于成人组(40%),少儿组免疫荧光呈“满堂亮”及肾组织中HBsAg、HBeAg、HBcAg三项均为阳性的比例(82%)明显高于成人组(64·7%)。结论在HBV-GN患者中,肾活检组织的免疫荧光大多表现为“满堂亮”(70·2%)。膜性肾病患者肾组织HBV抗原的检出和免疫荧光“满堂亮”的现象明显高于其它类型的HBV-GN。少儿的HBV-GN主要以MN为主,而成人的病理分型逐渐多样化。
出处 《中国热带医学》 CAS 2005年第5期1053-1054,共2页 China Tropical Medicine
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