摘要
针对骨科疾病治疗中传统的用药方式存在的问题,研究制备了一种生物可吸收靶向式药物控释载体。首先在体外模拟天然骨的生物矿化过程,利用材料的自组装机制合成了羟基磷灰石/胶原类骨仿生复合材料,再采用热致分相/非溶剂抽提成孔技术进一步与聚乳酸复合制备了三维多孔储存式药物控释载体。通过对材料的表征和模型化合物控释实验,结果显示羟基磷灰石/胶原复合材料与天然骨类似,羟基磷灰石/胶原/聚乳酸储存式载体能达到控制释放的目的。
Concerning the resolution of drawbacks existing in traditional drug administration, fabrication of bioabsorbable control-released drug carrier was investigated. Firstly hydroxyapatite/collagen bone-like biomimetic composite was synthesized through self-organization mechanism of materials stimulating in vitro biomineralization process of nature bone, which was further synthesized with polylactide and the 3D porous reservoir control-released drug carrier was fabricated by thermal-induced phase separation techniques/non-solvent extraction pore leaching technology. Characterization of the specimens and release test of model compound indicated similarities of hydroxyapatite/collagen composite to nature bone and availability for control release of hydroxyapatite/collagen/polylactite drug carrier respectively.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2005年第7期1059-1061,1068,共4页
Journal of Functional Materials
基金
武汉理工大学重点科学研究基金对本项目的大力支持.
关键词
生物可吸收
储存式
控释载体
自组装
热
致分相
Biomaterials
Drug therapy
Extraction
Health care
Hydrothermal synthesis
Nanostructured materials
Orthopedics
Phase separation
Transmission electron microscopy
X ray diffraction analysis
