摘要
本文综述培哚普利、雷米普利、贝那普利、喹那普利、福辛普利等新型血管紧张素转换酶抑制剂的药物动力学特点，以及在高血压、充血性心力衰竭的临床应用近况。与卡托普利比较，它们大多半衰期长、作用持久、服用方便（每日１次），不良反应相似但发生率略低。预期在今后心血管疾病治疗中将发挥重要作用。
The
pharmacokinetics and the clinical use in hypertension and congestive heart failure of new
angiotensin converting en-zyme inhibitors(perindopril),ramipril
,benazepril,quinapril,fosinopril,et al ) was reviewed. Comparing with captopril,these new drugs
have longer T_(1/2) and lasting time in effect,less adverse effect and are more convenient for
oral use. It is predi-cated that the new angiotension coverting enzyme inhibitors willplay an
important role in the treatment of cardiovascular dis-ease in future time.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1995年第6期274-275,共2页
Chinese Journal of Hospital Pharmacy
关键词
血管紧张素
转换酶
抑制剂
高血压
心力衰竭
angiotensin
converting enzyme inhibitor,hypertension , congestive heart failure ,left ventricular
hypertro-phy
