摘要
目的考察睾酮固体脂质纳米粒(SLN)体内药物动力学,讨论其临床意义。方法以睾酮作为模型药物,溶剂扩散法制备SLN,考察其理化性质、体外释放特性和大鼠口服睾酮SLN后药物动力学。结果制备所得载药纳米粒粒径为(389.1±113.6)nm,表面电位为(-29.8±3.2)mV,药物包封率为(42.3±6.4)%,大鼠口服睾酮SLN后,0￣48h相对生物利用度为259.3%;其血药浓度-时间曲线出现双峰现象。结论以SLN为载体睾酮口服后生物利用度大幅提高,可减少对肝脏的副作用,使睾酮的口服给药成为可能。
Objective To examine the pharmacokinetic properties of solid lipid nanoparticles （SLN） of testosterone. Methods Testosterone was used as model drug, and SLN was prepared by solvent diffusion method. The physicochemical property and pharmacokinetics of SLN were investigated. Results For the prepared SLN, the size of particles was （389.1 ± 113.6 ）nm, zeta value was （ -29.8 ± 3.2 ）mV and entrapment efficiency was （42.3 ± 6.4 ）%. The 0～48 h relative bioavailability was 259.3%. Conclusion SLN of testosterone can increase the bioavailability markedly, reduce side effect of the liver and can be administrated orally.
出处
《浙江医学》
CAS
2008年第7期698-700,共3页
Zhejiang Medical Journal
关键词
睾酮
固体脂质纳米粒
口服
生物利用度
Testosterone Solid lipid nanparticles Peroral administration Bioavailability
