摘要
目的探讨胆道化学性栓塞在肝内胆管结石治疗中的应用价值。方法应用肝内胆管结石动物模型评估胆道化学性栓塞能否达预防结石复发和化学性肝切除的效果。结果栓塞胆管的粘膜上皮完全消失,被增生的胶原纤维取代,从而有效的根除了慢性增生性胆管炎;各级靶胆管腔均被栓塞剂填充,因而也无结石产生。在栓塞肝叶的周边部可见完全纤维化区域,达到了化学性肝切除的效果,并有效的解决肝内胆管狭窄和结石复发的问题。结论胆道化学性栓塞有可能达到预防结石产生的目的,同时也可能达到化学性肝切除的效果。
Objective To investigate the value of applying chemical biliary duct embolization (CBDE) in treating hepatolithiasis. Methods The animal model of hepatolithiasis was used to analysis the feasibility of chemical hepatectomy and preventing stone recurrence via CBDE. The clinical effect of CBDE was also preliminarily investigated. Results The mucosa of embolized biliary duct entirely disappeared and were replaced by collagenous fiber, thus effectively eradicating the chronic proliferative cholangitis. The target biliary ducts of various sizes were all filled with embolized reagent, thus allowing no stone formation. In the periphery of embolized lobe, the hepatocytes entirely disappeared, indicating that the desired effects of chemical hepatectomy were achieved. As revealed in clinical study, the problems of intrahepatic biliary stricture and calculous recurrence could be effectively resolved by CBDE through biliary endoscopy. Conclusions Chemical biliary duct embolization might be a promising approach for preventing stone recurrence and the effect of chemical hepatectomy can be achieved.
出处
《消化外科》
CAS
CSCD
2005年第4期233-236,共4页
Journal of Digestive Surgery
关键词
肝内胆管结石
胆道
栓塞
肝切除
hepatolithiasis biliary duct embolization hepatectomy
