摘要
目的研究熊去氧胆酸（优思弗，UDCA）在预防胆管结石内镜逆行胰胆管造影（ERCP）术后复发中的作用。方法选择2005年3月至2006年9月间在我院消化科行ERCP术的胆管结石患者275例，随机分为实验组和对照组，实验组133例，术后服用熊去氧胆酸，对照组142例，术后未服用熊去氧胆酸，随访1年，观察有无结石复发，同时检测其血脂水平。结果实验组结石复发8例（8／133），复发率为6．01％，对照组复发20例（20／142），复发率为14．08％，两组复发率比较差异有统计学意义（P〈0．05）。实验组血清胆固醇较对照组明显下降，差异有统计学意义（P〈0．05），而甘油三酯及高密度、低密度脂蛋白比较差异无统计学意义（P〉0．05）。结论胆管结石ERCP术后服用熊去氧胆酸可有效预防结石的复发，熊去氧胆酸降低血清胆固醇水平可能是其预防复发的机制之一。
Objective To investigate the role of UDCA on preventing cholecystolithiasisbiliary recrudescence after ERCP. Methods Two hundred and seventy -five patients with cholecystolithiasis- biliary who had been treated with ERCP from March 2005 to September 2006 were randomly divided into experimental group （n = 133） and control group （n = 142）. Patients of experimental group took UDCA, while patients of control group didn＇ t take UDCA. All patients had been followed up for one year. The stone recrudescence was observed and the level of blood lipids were measured. Results There were 8 cases （8/133） with stone recurring in experimental group, while the control group recurred 20 cases （20/142）. The recurrence rate of two groups had significant statistics difference （ P 〈 0.05 ）. The level of serum cholesterol in the experimental group was lower than the control group, the difference had statis- tics significance （ P 〈 0.05 ）. But the differences in TG, HDL and LDL had no significance （ P 〉 0. 05）. Conclusions Taking UDCA could effectively prevent the stone recrudescence after ERCP,one of the possible mechanisms was that UDCA could reduce the level of serum cholesterol.
出处
《中国实用医刊》
2009年第6期28-29,共2页
Chinese Journal of Practical Medicine
