摘要
壳聚糖通过与丙烯酸接枝共聚制得壳聚糖聚丙烯酸悬浮液,在铁磁流体(Fe3O4)与聚乙二醇(分散剂)存在下通过与戊二醛交联,制备了磁性壳聚糖聚丙烯酸微球。用扫描电镜、红外光谱对合成的高分子微球进行形貌观察和结构表征,并进行了元素分析和磁性能测试,研究了磁性微球对牛血清白蛋白(BSA)的吸附效果。结果表明,合成的磁性微球外表呈球形,粒径为100～400nm;当Fe含量为2.47%时,磁性微球的饱和磁化强度约为1.30emug,磁矫顽力为280Oe,磁化率为2.16×10-4(常温下),属于顺磁性材料;其对BSA有较好的吸附效果,饱和吸附量约为400mgg。
In this study,chitosan(CS)-poly(acrylic acid)(PAA) suspension had been synthesized by graft polymerization of acrylic acid(AA) in chitosan solution. Then magnetic chitosan(CS)-poly(acrylic acid)(PAA)microspheres were prepared by the cross-linking of glutaraldehyde with the graft copolymer(CS-PAA) in the presence of polyethylene glycol(PEG)and magnetic fluid(Fe3O4). The physicochemical properties of the microspheres were investigated by using SEM,FT-IR,element analysis,magnetometry. The results showed that the shape of the microspheres was spherical,and their sizes were smaller (100～400nm). The quantity of Fe is 2.47%. As far as their magnetization characteristic concerned,their susceptibility was about 2.16×10 -4,and the best magnetic quality was around 1.30emu/g at 5kg magnetic field intensity. They were paramagnetic materials. Finally the magnetic chitosan(CS)-poly(acrylic acid)(PAA) microspheres were loaded with Bovine Serum Albumin(BSA)as model drug. The results showed that the quantity of immobilization was about 400mg/g with a better absorption.
出处
《化学通报》
CAS
CSCD
北大核心
2005年第7期551-554,共4页
Chemistry
