摘要
对７例细支气管肺泡癌合并肺纤维化及４例单纯性肺纤维化手术病例，进行病理形态及免疫组织化学检查，讨论了肺泡上皮腺瘤样增生（ＡＨ）的形态、组织发生及与细支气管肺泡癌的关系。根据光镜下形态学改变特点，将ＡＨ分为Ⅰ、Ⅱ两型，本组Ⅰ型ＡＨ６例、Ⅱ型ＡＨ５例。抗ＳＡ、抗ＳＳＥＡ－１及抗ＣＥＡ单抗检查结果表明，ＡＨ是慢性炎症性肺疾患时肺泡上皮出现的非特异性增生性病变，Ⅰ、Ⅱ两型ＡＨ均来源于Ｂ型肺泡上皮细胞；后者在前者基础上发展形成，较前者更具幼稚化倾向及增生能力，为一种癌前病变。细支气管肺泡癌中一部分起源于Ｂ型肺泡上皮细胞，可以认为其中有的是经Ⅱ型ＡＨ癌变而形成。
Abstract Surgical specimens of 7 cases of bronchioalreolar
carcinoma complicated with pulmonaryfibrosis and 4 cases of simple pulmonary fibrosis were
examined histopathologically and immunohistochemically.The morphology and histogenesis of
adenomatous hyperplasia(AH)ofalveolar epithelium and its rdlation to btonchioalveolar
carcinoma were investigated.The AH wasclassified as types Ⅰand Ⅱaccording to their
microscopic morphologic characteristics.In this group,6 cases of type Ⅰ-AH and 5 cases type
Ⅱ-AH were observedThe results of anti-SA, an-ti-SSEA-1 and anti-CEA monoclonal antibody
examinations indicate that AH is a nonspecifichyperplastic lesion of alveolar epithelium occurre
d during chronic pulmonary inflammatory diseases.Both type Ⅰ and Ⅱ AH originated from type
B alveolar epithelial cellsThe latter developed on the basis of the formerbut with a more
immatute tendency and byperplastic pltemtialbeing apre-malignant alterationIt could be
considered that certain ca ses of bronchioalveolar carcinomaa are originated form type B
alveolar epithelial cells,some of which underwent malignant changefrom type Ⅱ alveolar
hyperplasia.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1994年第2期141-143,T004,共4页
Chinese Journal of Oncology
