摘要
目的:探讨肾衰胶囊延缓慢性肾功能衰竭(CRF)进展及抗肾间质纤维化的机理。方法:74例失代偿期慢性肾功能衰竭患者随机分为治疗组和对照组。观察两组血清尿素氮(BUN)、肌酐(SCr)、内生肌酐清除率(Ccr)、Ⅳ型胶原(ColⅣ)、Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)的变化,尿蛋白(uPro)、尿β_2-微球蛋白(β_2-MG)及临床症状和体征的改善情况。结果:肾衰胶囊治疗后,CRF 患者 BUN、SCr 下降,Ccr 上升,血清 Col Ⅳ、PCⅢ、LN 下降,尿蛋白、尿β_2-微球蛋白下降,除 LN 外,其他各项与对照组比较差异均有显著性(P<0.05),临床症状和体征改善明显。结论:肾衰胶囊通过降低血清 BUN、SCr,升高 Ccr,改善肾功能,从而延缓慢性肾功能衰竭进展;减少细胞外基质、ColⅣ、LN 的沉积,从而干预肾间质纤维化。
Objective:To probe into the mechanism of Shenshuai Capsule in delaying advance of chronic renal failure(CRF)and against interstitial renal fibrosis.Methods:74 cases of CRF at decompensation phase were randomly divided into a treatment group and a control group.Changes of their serum urea nitrogen(BUN),creatinie(SCr),endogenous creatinine clearance rate(Ccr),collegen Ⅳ (Col Ⅳ),procollagen Ⅲ(PC Ⅲ),laminin(LN),and improvement of urinary protein(uPro),urinary β_2-microglobulin(β_2-MG)and clinical symptoms and signs were observed.Results:After treatment of Shenshuai Capsule,BUN,SCr,Col Ⅳ,PC Ⅲ,LN,urinary protein and β_2-MG decreased and Ccr increased in the treatment group,with a significant differences between the two group in the above mentioned indexes except LN(P<0.05);And the clinical symptoms and signs improved.Conclusion:Shenshuai Capsule delays the advance of chronic renal failure by means of decreasing BUN,SCr and increasing Ccr and improving renal function;and reduces the deposition of extracellular substrate,Col Ⅳ and LN so as to interfere interstitial renal fibrosis.
出处
《中医杂志》
CSCD
北大核心
2005年第5期348-350,共3页
Journal of Traditional Chinese Medicine
