摘要
本实验以卒中易感型自发性高血压大鼠(SHRSP)与京都种正常对照大鼠(WKY)为实验对象,用激光多普勒血流仪监测SHRSP卒中发生后的软脑膜微循环改变状态以及第二代钙离子拮抗剂——尼莫地平的治疗作用。结果发现:SHRSP脑血流量明显降低;31.2％(WKY54.0％)。脑微血管自律运动严重障碍。微血管运动频率高达30.6次/分(wKY 6.4次/分),而其血管运动振幅极度降低;38.7％(WKY 57.3％)。以上各值与对照组相比均有显著差异(P<0.05)。用尼莫地平后SHRSP脑血流量比用药前显著提高;69.5％(P<0.01)。血管运动频率由30.6次/分降为10次/分(P<0.05)。振幅由38.7％增至78.1％(P<0.01)。以右旋糖酐40与尼莫地平联合治疗后SHRSP脑血流量由31.2％增至113.0％;微血管运动频率降至7.3次/分,比右旋糖酐40或尼莫地平单一疗效明显增强(P<0.01).
The SHRSP and WKY cerebral microcirculatory blood flow volume (MBV) and vasomotive frequency (VF) and amplitude (VA) were measured by means of a computerized Laser Doppler Flowmeter system. It was found that during acute stroke of SHRSP the MBV was reduced, the VF was increased and the VA was diminished significantly. Respective intravenous injection of Nimodipine (N), or Dextran40 (D) could improve the above microcirculatory disturbances. However, injection of a mixture of N and D (1:40) demonstrated much better efficiency.
出处
《微循环学杂志》
1992年第3期1-6,共6页
Chinese Journal of Microcirculation
