摘要
目的观察受肿瘤侵害的神经干组织学形态,探讨肿瘤侵害神经干的发生机制。方法12例肢体恶性肿瘤伴有神经损害症状的截肢标本,解剖出受侵段神经干。大体观察及石蜡切片,HE染色、变色酸染色,显微镜下观察。结果12例中,7例神经受肿瘤挤压、推移,但神经外膜完好,无肿瘤细胞浸润。3例神经干一侧面受侵及,神经外膜不完整。肿瘤细胞侵及神经外膜,轴突增粗、空泡变及脱髓鞘。2例神经干完全受侵及,神经外膜完全破坏,肿瘤细胞侵及神经束膜。结论肢体恶性肿瘤早期对神经干以机械性压迫损害为主,随病程进展,肿瘤细胞侵及神经外膜,甚至神经束膜。
Objective To observe the pathological characteristics of nerve trunk impaired by malignant tumor and to explore the mechanism of tumor damage on nerve trunk. Methods The segments of nerve damaged by tumor were harvested from 12 patients with malignant tumor on limb, who had neurological symptoms of nerve impaired by the tumor and received amputation at different level. Paraffin sections of surgical specimens were stained with hematoxylin and eosin and chromotropic acid and observed under light microscope. Results Among 12 cases, 7 nerves were compressed and pushed by the tumor and the epineurium was intact and no tumor cells invasion was found. 3 cases were found one side nerve invaded by the tumor cells and the epineurium was not intact and tumor cells were found. Nerve demyelinated, axons swollen, disintegrated and lower density were found. In 2 cases, the nerves were thoroughly invaded by the tumor cells and epineurium was completely destroyed. Tumor cells were found at perineurium. Conclusions Tumor growth results in a progressive invasion to the nerve and causes mechanical damage at earlier stage. As the tumor expands, the tumor cells invade the epineurium and even the perineurium.
出处
《临床骨科杂志》
2005年第3期208-210,共3页
Journal of Clinical Orthopaedics
关键词
周围神经系统肿瘤
肿瘤浸润
脊神经
peripheral nervous system neoplasms
tumor infiltration
spinal nerves
