摘要
用双抗体夹心酶联免疫吸附试验检测５４例慢性粒细胞白血病（ＣＭＬ）患者血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平。结果显示：各期ＣＭＬ患者血清ｓＩＬ－２Ｒ水平均显著高于正常对照，且和病情的严重程度密切相关，ＣＭＬ急变治疗后，有效者血清ｓＩＬ－２Ｒ水平显著低于化疗前；无效者血清ｓＩＬ－２Ｒ不低，甚至高于化疗前。急粒变时血清ｓＩＬ－２Ｒ水平与外周血白细胞数、原始粒细胞绝对数及骨髓原始粒细胞绝对数呈正相关。血清ｓＩＬ－２Ｒ水平可作为ＣＭＬ分期、监测ＣＭＬ急变、判定预后的一个有用的指标。
he levels of soluble interleukin-2 receptor (sIL-2R )were evaluated in the sera of 54 patients with chronicmyelogenous leukemia (CML ) with enzyme-linkedimmunosobent assay ( ELISA ). The rcsultsdemonstrated that the levels of sIL-2R in CML weresignificantly elevated as compared with normal age-matched controls. 27 CML patients in chronic phase and9 patients in accelerated phase had slightly higher serumsIL-2R levels (327. 41±51. 19 and 803 ±197. 86U/ml ,respectively) than controls. 18 CML patients withblastic crisis showed much higher serum sIL-2R levels( 2559 ±1022U/ml, P< 0. 05). Furthermore , the seraof patients with CML biastic crisis after effective therapyshowed significantly decreased sIL-2R levels than thoseat initial diagnosis of blastic crisis and those at ineffectivetherapy. In 13 patients with CML blastic crisis(myeloid) the serum sIL-2R levels were corelated withthe absolute number of leukocytes or blasts in peripheralblood and in bone marrow.These results suggested that the serum level of sIL-2Ris a useful clinical indicator in monitoring differentphases of CML and the effectiveness of the treatment.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第1期23-24,53-54,共2页
Chinese Journal of Hematology
关键词
白细胞介素2
受体
白血病
慢性
e Soluble interleukin-2 receptor Chro-nic myelogenous leukemia
