摘要
用ＡＢＣ和ＩＧＳＳ法对１０例膀胱组织，２例腺性膀胱炎组织，１例膀胱异位嗜铬细胞瘤组织的癌胚抗原进行免疫组化变化的研究，结果表明１０例癌组织的染色均为阳性，阳性率为１００％。２例腺性膀胱炎和１例异位嗜铬细胞瘤组织为阴性，ＣＥＡ在阳性染色的膀胱癌组织中的定位主要为胞膜、胞浆混合型。阳性细胞在膀胱癌组织中的分布主要在上皮的表层，检查膀胱组织ＣＥＡ可以作为膀胱癌诊断和鉴别诊断的一种手段。
The CEA of tumor
tissue was observedunder immunohistochemical method including10 bladder cancer,2
glandular cystitis and 1ectopic pheochromocytoma of bladder by ABC3nd IGSS methods in this
test.The results showed that all tissues of bladder cancer werepositive staining. The CEA
positive rate was100%. The tissue of which in 2 glandular cys-titis and 1 ectopic
pheochromocytoma of blad-der were negative. The localized forms of CEAin these positive
staining cells was predomi-nantly complex pattern of apical and cytoplas-mic. The distribution
of positive cells in blad-der cancer tissue was mainly localization in thesurface of epithelium.
Thus the examination oftissue CEA may serve as a method for diagno-sis and differential
diagnosis of bladder can-cer. Meanwhile immunopathologic evidence,which monoclonal
antibody to monitor CEA,was used by R Ⅱ for detecting of bladder can-cer and the metastases.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1994年第6期357-358,共2页
Chinese Journal of Experimental Surgery
关键词
癌胚抗原
免疫组织化学
膀胱肿瘤
单克隆抗体
bladder cancer carcinoem-bryonic antiger monoclonal immunohis-tochemistry
